Rubio-Cervilla, Jon; Frisch, Hendrik; Barner-Kowollik, Christopher; Pomposo, Jose A. published the artcile< Synthesis of Single-Ring Nanoparticles Mimicking Natural Cyclotides by a Stepwise Folding-Activation-Collapse Process>, Safety of 1-(Chloromethyl)-4-vinylbenzene, the main research area is chloromethylstyrene styrene copolymer cyclized azidated CuAAC crosslinked cyclotide mimetic; RAFT polymerization; cyclic polymers; photochemistry; single chain folding; single chain nanoparticles.
Cyclotides are small cyclic polypeptides found in a variety of organisms, ranging from bacteria to plants. Their ring structure endows those polypeptides with specific properties, such as improved stability against enzymic degradation Optimal cyclotide activity is often observed only in the presence of intra-ring disulfide bonds. Synthesis of soft nano-objects mimicking the conformation of natural cyclotides remains challenging. Here, a new class of natural cyclotide mimics synthesized by a stepwise folding-activation-collapse process at high dilution starting from simple synthetic precursor polymers is established. The initial folding step is carried out by a photoactivated hetero Diels-Alder (HDA) ring-closing reaction, which is accompanied by chain compaction of the individual precursor polymer chains as determined by size exclusion chromatog. (SEC). The subsequent activation step comprises a simple azidation procedure, whereas the final collapse step is driven by CuAAC in the presence of an external crosslinker, providing addnl. compaction to the final single-ring nanoparticles (SRNPs). The unique structure and compaction degree of the SRNPs is established via a detailed comparison with conventional single-chain nanoparticles (SCNPs) prepared exclusively by chain collapse from the exact same precursor polymer (without the prefolding step). The stepwise folding-activation-collapse approach opens new avenues for the preparation of artificial cyclotide mimetics.
Macromolecular Rapid Communications published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Safety of 1-(Chloromethyl)-4-vinylbenzene.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics