Rosen, Brandon R.; Ul Sharif, Ehesan; Miles, Dillon H.; Chan, Nicholas S.; Leleti, Manmohan R.; Powers, Jay P. published the artcile< Improved synthesis of sterically encumbered heteroaromatic biaryls from aromatic β-keto esters>, Product Details of C8H4ClF3O2, the main research area is sterically hindered aryl aminopyrimidine preparation keto ester guanidine condensation.
A protocol for the synthesis of hindered 4-aryl 2-aminopyrimidines from β-keto esters is described. The process employs trifluoroethanol as an essential additive to promote the guanidine condensation reaction, enabling the synthesis of 25 aryl- and heteroaryl substituted aminopyrimidines in good yields and high purities with no column chromatog. The conditions described herein are readily scalable and have been employed in the large-scale synthesis of the clin. A2a/A2bR antagonist AB928.
Tetrahedron Letters published new progress about Aminopyrimidines Role: SPN (Synthetic Preparation), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics