Bolous, Mina; Arumugam, Natarajan; Almansour, Abdulrahman I.; Suresh Kumar, Raju; Maruoka, Keiji; Antharam, Vijay C.; Thangamani, Shankar published the artcile< Broad-spectrum antifungal activity of spirooxindolo-pyrrolidine tethered indole/imidazole hybrid heterocycles against fungal pathogens>, Safety of (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is spirooxindole pyrrolidine indole imidazole hybrid antifungal; 1,3-Dipolar cycloaddition; Antifungal agent; Candida; Cryptococcus; Fungi; Ionic liquids; Minimum inhibitory concentration (MIC); Spirooxindolo-pyrrolidine tethered indole/imidazole; Toxicity.
Invasive fungal infections are one of the leading causes of nosocomial bloodstream infections with a limited treatment option. A series of derivatized spirooxindolo-pyrrolidine tethered indole and imidazole heterocyclic hybrids have been synthesized, and their antifungal activity against fungal strains were determined Here we characterize the antifungal activity of a specific spirooxindolo-pyrrolidine hybrid, dubbed compound 9c (I), a spirooxindolo-pyrrolidine tethered imidazole synthesized with a 2-chloro and trifluoromethoxy substituent. The compound 9c exhibited no cytotoxicity against mammalian cell line at concentrations that inhibited fungal strains. Compound 9c also significantly inhibited the fungal hyphae and biofilm formation. Our results indicate that spirooxindolo-pyrrolidine heterocyclic hybrids potentially represent a broad class of chem. agents with promising antifungal potential.
Bioorganic & Medicinal Chemistry Letters published new progress about 1,3-Dipolar cycloaddition reaction, regioselective. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Safety of (E)-1-Chloro-4-(2-nitrovinyl)benzene.
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