Sun, Caocao; Yin, Guoyin published the artcile< Integrating aryl chlorides into nickel-catalyzed 1,1-difunctionalization of alkenes>, Application of C6H3ClF2, the main research area is secondary benzyl boronate preparation regioselective; alkene aryl chloride bispinacolatodiboron difunctionalization nickel catalyst.
Herein, a first achievement in 1,1-difunctionalization of alkenes RCH=CH2 (R = hexyl, cyclohexyl, 3-(1H-pyrrol-1-yl)propyl, 9H-carbazol-9-ylmethyl, etc.) with aryl chlorides ArCl (Ar = Ph, 2,4-difluorophenyl, 1-[(tert-butoxy)(oxo)methane]-1H-indol-6-yl, 2H-1,3-benzodioxol-5-yl, etc.) as coupling partners was reported. The success is predominantly ascribed to the judicious selection of 1,2-diamine ligand. This study provides an efficient protocol for the synthesis of secondary benzyl boronates RCH2CH(R1)Ar (R1 = tetramethyl-1,3,2-dioxaborolan-2-yl) from easily accessible feedstock chems. Furthermore, the distinguished features of this method include excellent 1,1-regio- and chemoselectivity, good functional group tolerance and easily-operational catalytic reaction conditions.
Chinese Chemical Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Application of C6H3ClF2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics