Li, Jia; Li, Yu-An; Wu, Ge; Zhang, Xu published the artcile< Metal-free aminohalogenation of quinones with alkylamines and NXS at room temperature>, Category: chlorides-buliding-blocks, the main research area is halo amino naphthalenedione preparation; naphthoquinone amine aminohalogenation; NXS; aminohalogenation; metal-free; quinones; radical reactions.
A simple and practical strategy for intermol. aminohalogenation of quinone with alkyl amines and NXS was developed for preparation of halo(amino)naphthalenediones I [X = H, Cl, Br, I; R1 = Me; R2 = 2-cyanoethyl, (4-bromophenyl)methyl, phenethyl, (3S)-3-(2-methylphenoxy)-3-phenyl-propyl; R1 = R2 = (CH2)2O(CH2)2, (CH2)2CH(OH)(CH2)2, (CH2)2CH(CO2Me)(CH2)2], in which haloamines generated in situ were employed as bifunctional reagents. The reaction system was reliable, efficient and wide in substrate range, which was suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals.
Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Halogenation (amino). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics