Month: February 2023

Substituent effects in substrates on activation parameters in the bimolecular nucleophilic reactions in solution was written by Vlasov, Vladislav M.. And the article was included in New Journal of Chemistry in 2010.Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

Changes of the activation parameters, ΔH^≠ and ΔS^≠, in the S_N2, S_NAr and acyl-transfer reactions with charged and neutral nucleophiles in various solvents were correlated with σ constants of the substituents in the aromatic ring of the substrates. The resultant δΔH^≠ and δΔS^≠ reaction constants are linearly related for variations of substituents at the substrate. Correlation of δΔH^≠ vs. δΔS^≠ allows one to estimate the contribution of changes of the internal enthalpy, δΔH^≠_int, to the enthalpy reaction constant, δΔH^≠, which gives a single linear dependence on the Hammett ρ reaction constants for all bimol. nucleophilic reactions. The deviations from dependence of δΔH^≠_int vs. ρ can be interpreted in terms of changes of the transition state structure or reaction mechanism. The results obtained show that the substituent effects in the substrates and nucleophiles on the charge development in the transition state are governed by the magnitude of δΔH^≠_int. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intramolecular reactions of N-nitrenes: oxidation of 3-amino-2-(arylalkyl)quinazolin-4(3H)-ones was written by Atkinson, Robert S.;Malpass, John R.;Woodthorpe, Katherine L.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1982.Synthetic Route of C9H9ClO2 This article mentions the following:

Oxidation of quinazolines I (R = OMe; R¹ = H, OMe; R² = NH₂; n = 2) with Pd(OAc)₄ in CH₂Cl₂ at room temperature gave I (same R, R¹, n; R² = H) (II) and the diazepines III (R = H, OMe; R¹ ≠ R² = H, OMe) via the corresponding N-nitrene intermediates. On oxidation under analogous conditions I (n = 2, R = H, R¹ = OMe; n = 1, R ≠ R¹ = H, OMe; R² = NH₂) gave only the deamination products II. Azepine formation involves electrophilic aromatic substitution by the nitrene on the aromatic ring via a 7-membered transition state. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation, characterization and catalytic study of a nano-inorganic composite of CuO/NiO for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water was written by Beni, Zohreh Hashemi;Albadi, Jalal;Kiyani, Hamzeh. And the article was included in Inorganic and Nano-Metal Chemistry.Application of 620-19-9 This article mentions the following:

In this research, a nano-inorganic composite of CuO/NiO is prepared by co-precipitation method as an efficient recyclable nanocatalyst for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water. The catalyst was characterized by several techniques such as the field emission SEM (FESEM), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), x-ray fluorescence, inductively coupled plasma at. emission spectroscopy (ICP-OES), and brunauer-emmett-teller (BET) surface area anal. The regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles was carried out from reaction of various benzyl halides or alkyl halides with Ph acetylene and sodium azide in water under reflux condition in high yields. The CuO/NiO nanocatalyst can be simply recovered and reused 6 runs without a significant slight in activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

5-HT_2C receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs was written by Jang, Jae Wan;Baek, Je-sook;Choi, Gil Don;Park, Woo-Kyu;Cho, Yong Seo;Baek, Du-Jong;Pae, Ae Nim. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: chlorides-buliding-blocks This article mentions the following:

Agonists of the 5-HT_2C receptor have attracted much attention as therapeutic agents for the treatment of obesity. Subtype selectivity against other 5-HT₂ receptors is one of the most important prerequisites for reducing side effects. We present the synthesis of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs and their structure-activity relationship studies on 5-HT_2A and 5-HT_2C receptors. Although the compounds showed nanomolar activity to the 5-HT_2C receptor, their selectivity against the 5-HT_2A receptor was modest to low. Mol. modeling studies using homol. modeling and docking simulation revealed that selectivity originated from subtype specific residues. The observed binding modes and receptor-ligand interactions provided us a clue for optimizing the selectivity against the 5-HT_2A receptor. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Concise synthesis of 3,4-dihydro-1,4-benzoxazines by three-component reactions of acyl chlorides, o-aminophenols and 1,2-dichloroethane was written by Liu, Yunyun;Chen, Xuwen. And the article was included in Tetrahedron in 2018.Product Details of 6834-42-0 This article mentions the following:

The Cu(OAc)₂-catalyzed three-component reactions of o-aminophenols R¹-2-NH₂C₆H₃OH (R¹ = H, 4-CH₃, 5-CH₃), acyl chlorides R²C(O)Cl (R² = C₆H₅, furan-2-yl, (E)-C₆H₅CH=CH, etc.) and 1,2-dichloroethane (DCE) have been established for the efficient synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazines (3,4-dihydro-1,4-benzoxazines) I (R³ = H, 6-CH₃, 7-CH₃). This method features advantages of the one-pot operation enabling N-acylation, C-Cl bond amidation and etherification, as well as the structural divergence of the synthesized products. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Product Details of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides and their evaluation as D₃ receptor ligands was written by Blass, Benjamin E.;Chen, Peng-Jen;Gordon, John C.. And the article was included in Medicinal Chemistry Research in 2022.COA of Formula: C19H15Cl This article mentions the following:

Cocaine use disorder (CUD) is a major, unmet medical need. This tropane alkaloid is one of the most commonly abused recreational drugs. In 2018, there were over 5.5 million cocaine users. Therapeutic options capable of addressing this issue are limited, as there are no approved pharmacotherapies. The D₃ dopamine receptor is a potential CUD therapeutic target that remains under active investigation. We have recently disclosed a series of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides typified by I that are potent D₃ ligands that have moderate to high selectivity for D₃ over D₂. We have continued our exploration of this series of compounds in an effort to identify compounds with improved microsomal stability such as II. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives was written by Li, Xu-Jun;Zhang, Wei;Zhao, Chi-Na;Wu, Qing-Lai;Li, Jun-Kai;Xu, Zhi-Hong. And the article was included in Journal of Asian Natural Products Research in 2021.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC₆H₄, 2-FC₆H₄, 2,4-Cl₂C₆H₃, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by ¹H-NMR, ¹³C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC₆H₄, 4-iPrC₆H₄, 4-tBuC₆H₄, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] were promising fungicidal candidates, deserving further studies. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nanofiltration membranes with enhanced performance by constructing an interlayer integrated with dextran nanoparticles and polyethyleneimine coating was written by Chen, Yuhao;Sun, Haixiang;Tang, Sihui;Feng, Huimei;Zhang, Hongbin;Chen, Kuo;Li, Peng;Niu, Q. Jason. And the article was included in Journal of Membrane Science in 2022.Recommanded Product: 4422-95-1 This article mentions the following:

The thin-film composite (TFC) nanofiltration (NF) membrane is a novel kind of membrane that has been extensively studied in recent years and broadly applied in desalination and wastewater treatment. The improvement of separation performance by optimizing the structure and morphol. of NF membranes can significantly reduce energy consumption and bring more economic benefits. In this work, glutaraldehyde (GA) was used to crosslink polyethyleneimine (PEI) and dextran nanoparticles (DNPs) to construct an interfacial coating interlayer on polysulfone (PSF) ultrafiltration (UF) substrate. Subsequently, the polyamide (PA) NF membranes were fabricated by interfacial polymerization (IP) between piperazine (PIP) and trimesoyl chloride (TMC). DNPs were semi-encapsulated in the PEI coating and the exposed nanoparticles would be embedded in the PA layer for forming interfacial channels after IP. The interlayer not only affected the adsorption and diffusion of aqueous phase monomers to form a thin membrane, but also improved the membrane d. to prevent selective defects associated with the incorporation of nanoparticles. The pure water permeance of the interlayered-TFC NF membrane was determined as 313.3 Lm^-2h^-1MPa^-1, which was approx. four-fold that of the pristine membrane. The retention rate of various divalent salts of the NF membrane also significantly improved, and the retention rate of Na₂SO₄ exceeded 99%. This innovative method of interlayer modification has exhibited great potential in rapid desalination and wastewater recovery, providing new possibilities for the preparation of industrial high-performance NF membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

(1-Adamantyl){4-[(2-chloro-9-isopropyl-9H-purin-6-yl)aminomethyl]phenyl}methanone trichloromethane solvate was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.SDS of cas: 203436-45-7 This article mentions the following:

In the title compound, C₂₆H₃₀ClN₅O·CHCl₃, the purine mol. consists of essentially planar benzene and purine ring systems [maximum deviation 0.010 (4) Å for both ring systems] forming a dihedral angle of 85.52 (9)°. Intermol. N-H…N hydrogen bonds link adjacent mols. into centrosym. dimers. The structure also contains intermol. C-H…O and C-H…N interactions. The benzene rings form offset face-to-face π-π stacking interactions with an interplanar distance of 3.541 (4) Å and a centroid-to-centroid distance of 4.022 (4) Å. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7SDS of cas: 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis was written by Madaiah, Malavalli;Prashanth, Maralekere K.;Revanasiddappa, Hosakere D.;Veeresh, Bantal. And the article was included in New Journal of Chemistry in 2016.Recommanded Product: 3-Cyanobenzoyl chloride This article mentions the following:

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacol. activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg^-1 body weight In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Recommanded Product: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics