Month: February 2023

Synthesis of derivatives of cyclobuteno[c]thiophene. Attempts to synthesize thiophene analogs of biphenylene was written by Ayres, B. E.;Longworth, S. W.;McOmie, J. F. W.. And the article was included in Tetrahedron in 1975.Reference of 36157-41-2 This article mentions the following:

The thiophenes I (R = R1 = I, CO2H, CH2OH, CH2Br, Me, CHBr2, CHO, CHCl2, CN, R2 = Cl) were prepared from I (R = R1 = H, R2 = Cl) by standard methods. I (R = R1 = CHO, R2 = Cl) reacted with PBr5 to give I (R = CHBr2, R1 = CHO, R2 = Cl; R = R1 = CHBr2, R2 = Cl, Br); the latter 2 compounds reacted with NaI to give the corresponding cis- and trans-dibromocyclobutathiophenes II. Reaction of trans-II (R2 = Cl) with N-bromosuccinimide resulted in bond fission and regeneration of I (R = R1 = CHBr2, R2 = Cl). I (R = R1 = I, R2 = Cl) reacted with BuLi and Me2SO4 to give I (R = R1 = Me, R2 = Cl) and the bis(thiophenindigo) III. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Reference of 36157-41-2).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 36157-41-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Progress in synthesis of intermediates for quinolone antibacterial agents was written by Xu, Zhaoyu. And the article was included in Huagong Keji Shichang in 2009.Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

New advance of some important intermediates for synthesizing quinolone antibacterial was introduced. These intermediates include 2,3,4-trifluoronitrobenzene, 2,4-dichloro-5-fluorobenzoic acid, 4-n-butyryl chloride, and ethyl-2,6-dichloro-5-fluoro nicotinoyl acetate, and 2,4-dichloro fluorobenzene etc. In addition, expounded improvement of some synthetic methods, such as 2,4-dichloro fluorobenzene, 2,4-dichloro-5-fluorobenzoic acid, etc. In synthesis of 1,2,3-trifluoro-4-nitrobenzene by two processes of nitration and fluorination with 1,2,3-trichlorobenzene as raw material, content of product was over 99%, and yield was 60%. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aza-BODIPY Route to Ageladine A was written by Tolle, Christian;Fresia, Marvin;Lindel, Thomas. And the article was included in Organic Letters in 2022.HPLC of Formula: 76-83-5 This article mentions the following:

The marine natural product ageladine A was synthesized by exploiting novel aza-BODIPY-type boron complexes that allowed the regioselective dibromination of the pyrrole unit, as confirmed by quantum chem. calculation (ωB97XD/TApr-cc-pVDZ). The parent tricycle was accessed by Suzuki-Miyaura cross-coupling employing Buchwald’s precatalyst. The boron complex of ageladine A exhibited strong fluorescence that was greater than that of the natural product by a factor of ~30 and that disappeared in the presence of 2-azido groups. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5HPLC of Formula: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iridium(III)-Catalyzed Regiocontrolled Direct Amidation of Isoquinolones and Pyridones was written by Das, Debapratim;Samanta, Rajarshi. And the article was included in Advanced Synthesis & Catalysis in 2018.Formula: C7H4ClF3O2S This article mentions the following:

Iridium(III)-catalyzed highly regiocontrolled C3/C8 amidation of isoquinolones and C6 amidation of 2-pyridones has been successfully accomplished with various azides. The optimized method is operationally simple with a broad substrate scope. The protocol has been found to be scalable. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, XRD, Hirshfeld surface analysis, DFT studies, cytotoxicity and anticancer activity of di(m-chlorobenzyl) (dichloro) (4, 7-diphenyl-1,10-phenanthroline) tin (IV) complex was written by Bhaskar, C.;Elangovan, N.;Sowrirajan, S.;Chandrasekar, S.;Ali, Ola A. Abu;Mahmoud, Samy F.;Thomas, Renjith. And the article was included in Journal of Molecular Structure in 2022.Related Products of 620-19-9 This article mentions the following:

The complex di(m-chlorobenzyl) (dichloro) (4, 7-diphenyl-1,10-phenanthroline) tin (IV) complex (B2) was synthesized and characterized by FT-IR, FT-Raman, ¹H NMR, ¹³C NMR, ¹¹⁹Sn NMR, and XRD. The above-synthesized complex compared with the theor. method using Gaussian software at DFT/B3LYP/Lanl2DZ. Wavefunctiona based properties like ELF and LOL helped to identify the electron distributions. X-ray study confirmed that compound crystallizes in monoclinic space group with P2₁/c,. The crystal structure of the B2 shows a regular octahedral geometry. Hydrogen bond formation is observed through chlorine anion via C-H-Cl. The complex showed excellent cytotoxicity and anticancer activity against Vero and Hela cell line when compared to the standard drug cisplatin. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The Precise Synthesis of Phenylene-Extended Cyclic Hexa-peri-hexabenzocoronenes from Polyarylated [n]Cycloparaphenylenes by the Scholl Reaction was written by Quernheim, Martin;Golling, Florian E.;Zhang, Wen;Wagner, Manfred;Raeder, Hans-Joachim;Nishiuchi, Tomohiko;Muellen, Klaus. And the article was included in Angewandte Chemie, International Edition in 2015.Category: chlorides-buliding-blocks This article mentions the following:

The longitudinal extension of cycloparaphenylenes (CPP) towards ultrashort carbon nanotubes (CNTs) is essential for the solution based bottom-up synthesis of CNTs. Herein, the longitudinal extension of the CPP skeleton by the introduction of hexaphenylbenzene units towards polyarylated [n]CPPs is described. Further, the applicability of the Scholl reaction to selectively form graphenic sidewalls is demonstrated. The ring size and substitution patterns of the polyarylated [n]CPPs were varied to overcome strain-induced side reactions during the oxidative cyclodehydrogenation and cyclic para-hexa-peri-hexabenzocoronene trimers ([3]CHBCs) were selectively obtained. This concept is envisioned as an access to ultrashort carbon nanotubes subject to the condition that further benzene rings with the right connectivity will be inserted. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2Category: chlorides-buliding-blocks).

5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Microwave-assisted synthesis of Benzimidazole derivatives through nitro reductive cyclization and their biological study was written by Manju, N.;Kalluraya, Balakrishna;Asma;Kumar, Madan S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2018.Formula: C9H8ClNO4 This article mentions the following:

A simple, effective and eco-friendly method was developed for the synthesis of 1,2-disubstituted benzimidazole derivatives I [R = Me, n-Pr, n-Bu; Ar = 4-HC≡CCH₂OC₆H₄, pyren-1-yl, 5-Cl-3-Me-1-phenyl-pyrazol-4-yl, etc.] via one-pot nitro reductive cyclization of Et 4-(alkylamino)-3-nitro-benzoates with aryl aldehydes using sodium dithionite reagent under microwave irradiation The newly synthesized compounds I were characterized by LC-MS, Fourier transform IR, ¹H-NMR, ¹³C-NMR, CHN anal. and also by X-ray diffraction method. The antioxidant activity studies indicated that compounds I [R = n-Pr, Ar = 5-oxido-3-(p-tolyl)oxadiazol-3-ium-4-yl; R = n-Bu, Ar = 5-oxido-3-(p-tolyl)oxadiazol-3-ium-4-yl; R = n-Bu, Ar = 2-chloro-3-quinolyl] having IC₅₀ values of 1.95, 1.27 and 4.08 were very potent against nitric oxide free radicals. Compound I [R = n-Bu, Ar = 2-chloro-3-quinolyl] exhibited comparable 2,2-diphenyl-1-picrylhydrazyl radical inhibition (76.57) with that of standard employed. The antimicrobial activity results indicated that compounds I [R = n-Bu, Ar = 5-oxido-3-(p-tolyl)oxadiazol-3-ium-4-yl; R = n-Pr, Ar = 4-HC≡CCH₂OC₆H₄; R = n-Bu, Ar = 5-Cl-3-Me-1-phenyl-pyrazol-4-yl] were moderately active against bacterial strains and rest of the compounds were moderately active against fungal strains. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Formula: C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors was written by Di Matteo, Mauro;Ammazzalorso, Alessandra;Andreoli, Federico;Caffa, Irene;De Filippis, Barbara;Fantacuzzi, Marialuigia;Giampietro, Letizia;Maccallini, Cristina;Nencioni, Alessio;Parenti, Marco;Soncini, Debora;Del Rio, Alberto;Amoroso, Rosa. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Electric Literature of C8H9ClO4S This article mentions the following:

The most frequently used treatment for hormone receptor pos. breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC₅₀ values that are similar to that of letrozole and SYN 20028567 were identified. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iodine-mediated neutral and selective N-Boc deprotection was written by Kumar, G. Pavan;Rambabu, D.;Rao, M. V. Basaveswara;Pal, Manojit. And the article was included in Journal of Chemistry in 2013.Reference of 18437-66-6 This article mentions the following:

A simple, efficient, and alternative method was developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under solvent-free conditions or in a solvent using I₂ as a catalyst. The methodol. involving the use of iodine for N-Boc deprotection of protected amines represents an effective and useful alternative to previously reported methods. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Polymer amino-protecting groups based on tert-butoxycarbonyl- and benzoylcarbonyl function-containing polymethacrylamides was written by Rehse, Henning;Ritter, Helmut. And the article was included in Makromolekulare Chemie in 1989.Related Products of 18437-66-6 This article mentions the following:

The synthesis of tert-butoxycarbonyl- and benzyloxycarbonyl-modified monomers was performed by the addition of p-ClC₆H₄NCO or PhCH₂NCO to the free OH groups of N-(2-hydroxy-2-methylpropyl)methacrylamide, N-(2-hydroxy-2-methylpropyl)-6-methylacrylamidohexanamide and N-β-hydroxyphenethylmethacrylamide. The monomers were homopolymerized and copolymerized with Me methacrylate. The kinetics of acidic-induced amine cleavage from the amino-protecting groups was followed by NMR spectroscopy, and the polymers were suitable amino-protecting groups. Ca²⁺ ions enhanced the rate of amine cleavage considerably. Neighboring group effects and the influence of comonomers and spacer groups on the reactivity of the urethane groups were also discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics