Month: February 2023

Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions was written by D’Hollander, Agathe C. A.;Romero, Eugenie;Vijayakumar, Kamsana;Le Houerou, Camille;Retailleau, Pascal;Dodd, Robert H.;Iorga, Bogdan I.;Cariou, Kevin. And the article was included in Advanced Synthesis & Catalysis in 2021.Application of 18437-66-6 This article mentions the following:

Ynamides was underwent a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the basic conditions and heat was reported. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gave access to various nitrogen-rich heterocycles. The reaction usually proceeded with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solid Supported Chiral N-Picolylimidazolidinones: Recyclable Catalysts for the Enantioselective, Metal- and Hydrogen-Free Reduction of Imines in Batch and in Flow Mode was written by Porta, Riccardo;Benaglia, Maurizio;Annunziata, Rita;Puglisi, Alessandra;Celentano, Giuseppe. And the article was included in Advanced Synthesis & Catalysis in 2017.Reference of 12083-92-0 This article mentions the following:

A new class of solid supported chiral imidazolidinone organocatalysts for the catalytic reduction of imines with trichlorosilane was developed. Polystyrene proved to be a more effective support than SiO₂ in terms of both chem. and stereochem. efficiency. Even with a loading ≥1 mol% the best performing supported catalyst showed a remarkable activity and stereocontrol ability, promoting the reduction with stereoselectivities reaching 98% ee and in most cases ranging between 90-95% ee The general scope of the methodol. and the good recyclability of the immobilized catalyst were demonstrated. The polystyrene-anchored chiral catalyst was also used to prepare packed bed reactors for the continuous flow synthesis of chiral amines, that were obtained in excellent yields and enantioselectivities. By exploiting the chiral organocatalytic reactor, the in-flow stereoselective synthesis of a common, immediate precursor of rivastigmine, of the calciomimetic (R)-NPS 568 and of Acrylamide (S)-A, currently under study for the treatment of neuropathic pain, was successfully accomplished. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Reference of 12083-92-0).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 12083-92-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-pot regio- and chemo-selective synthesis of thiaazatricyclododecane was written by Alizadeh, Abdolali;Bagherinejad, Akram;Bayat, Fahimeh;Zhu, Long-Guan. And the article was included in Tetrahedron in 2016.Formula: C7H3Cl2NS This article mentions the following:

A highly regio- and chemo-selective heteroannulation protocol for the synthesis of unreported polysubstituted thiaazatricyclododecanes I (R¹ = H, Br, Cl, OCH₃; R² = H, Cl; R³ = H, Br; R⁴ = H, Cl, F) has been developed by a sequential four-component reaction of isoquinoline, 2-bromoacetophenones R¹C₆H₄C(O)CH₂Br, aryl isothiocyanates 2-R²-3-R³-4-R⁴-C6H2NCS, and Me 4-chloro-3-oxobutanoate under mild conditions in CH₃CN. The method features formation of various C-N, C-S, and C-C bonds, low-cost and readily available substrates, as well as simple one-pot operation, which makes this process highly profitable. This synthesis serves as a nice addition to chem. in which purification via chromatog. and recrystallization can be avoided, and the pure products were obtained simply by washing the crude products with hexane-Et acetate (10:1). In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ni-Catalyzed Enantioselective Benzylation of Secondary Phosphine Oxide was written by Cai, Wen-Qiang;Wei, Qi;Zhang, Qing-Wei. And the article was included in Organic Letters in 2022.Product Details of 620-19-9 This article mentions the following:

A nickel-catalyzed benzylic substitution of secondary phosphine oxide was described, affording the dialkylated P-stereogenic tertiary phosphine oxides with high to excellent enantioselectivities. The reaction was performed under mild conditions with com. available benzyl chlorides and bench stable secondary phosphine oxides, exhibiting broad functional group tolerance. It represented a practical example for the preparation of P-stereogenic phosphine compounds In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Product Details of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Factorial design, physical studies and rapid arsenic adsorption using newly prepared polymer modified perlite adsorbent was written by Saleh, Tawfik A.;Tuzen, Mustafa;Sar, Ahmet;Altunay, Nail. And the article was included in Chemical Engineering Research and Design in 2022.Recommanded Product: Trimesoylchloride This article mentions the following:

In this work, expanded perlite (EP) was modified with a polymer of trimesoyl chloride and phenylenediamine, and evaluated as a novel competent adsorbent for aquatic arsenic (As(III)) removal. The chem. structure and morphol. of the developed polymer-modified EP (PM-EP) adsorbent were investigated by Fourier transform IR spectroscopy, as well as scanning electron microscope /energy equipped with dispersive X-ray spectroscope. The conditions of batch removal such as the solution pH, contact time, sorbent dosage, and initial As(III) concentration were analyzed by factorial design. Based on the non-linear and linear Langmuir model that well correlates equilibrium data, the removal capacity of the produced PM-EP adsorbent was estimated as 447.9 mg g^-1 and 454.5 mg g^-1, resp. at optimized conditions (pH: 6; contact time: 60 min; adsorbent dosage: 10 g L^-1 and temperature: 24°C). The As(III) adsorption mechanism onto PM-EP adsorbent was well described by the non-linear pseudo-second-order kinetic model. The prepared PM-EP adsorbent was subjected to a ten cycling-adsorption/desorption test and the results demonstrated that it had appreciated reuse performance until seven cycles. The removal efficiency of PM-EP was determined in the case of wastewater samples. The overall evaluation suggested that the synthesized PM-EP adsorbent could be a powerful alternative adsorbent for decontamination of As(III) ions from wastewaters and drinking waters. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Halogenated carbonyl ylides in the reactions of mercurial dihalocarbene precursors with substituted benzaldehydes was written by Martin, Charles W.;Lund, Paul R.;Rapp, Erich;Landgrebe, John A.. And the article was included in Journal of Organic Chemistry in 1978.Computed Properties of C9H9ClO2 This article mentions the following:

The reactions of PhHgCBrCl₂ (I) with RC₆H₄CHO [R = H (II), 3-CF₃ (III), 4-MeO (IV)] and 2,4,6-Me₃C₆H₂CHO were studied. Relative reactivities with respect to I were III (0.08), II (0.3), BuCH:CH₂ (0.3), IV (0.9), cyclohexene (1.0), and Me₂C:CMe₂ (15.0). Complexation between I and the aldehyde enhanced the rate of decomposition of I to produce :CCl₂ of the same reactivity as that from I alone. The intermediacy of dichlorocarbonyl ylides was proposed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Computed Properties of C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scalable Methodology for the Catalytic, Asymmetric α-Bromination of Acid Chlorides was written by Dogo-Isonagie, Cajetan;Bekele, Tefsit;France, Stefan;Wolfer, Jamison;Weatherwax, Anthony;Taggi, Andrew E.;Lectka, Thomas. And the article was included in Journal of Organic Chemistry in 2006.Reference of 6834-42-0 This article mentions the following:

The optimization of a practical, catalytic, asym. process for the α-bromination of acid chlorides to produce synthetically versatile, optically active α-bromo esters was reported. A range of products was produced in high enantioselectivity and moderate to good chem. yields with retention of both upon scale-up. The reactions were catalyzed by cinchona alkaloid derivatives with the best performance achieved by the use of a proline cinchona alkaloid conjugate designed in a de novo fashion. Thus, PhCH₂COCl in THF containing NaH, 15-crown-5, and the ester of N-Boc-proline with quinine at -78° reacted with 1,1,3,6-tetrabromo-2(1H)-naphthalenone for five hours to give 55% of the tribromonaphthyl bromophenylacetate I with 99% enantiomeric excess. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Azo-functionalized microporous organic polymers: synthesis and applications in CO₂ capture and conversion was written by Yang, Zhenzhen;Zhang, Hongye;Yu, Bo;Zhao, Yanfei;Ma, Zhishuang;Ji, Guipeng;Han, Buxing;Liu, Zhimin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Product Details of 698-01-1 This article mentions the following:

Azo-functionalized MOPs (Azo-MOPs) were synthesized via oxidative polymerization of aromatic amines catalyzed by t-BuOCl/NaI (25 °C, 1 h, yield: >95%), which displayed an excellent coordinating ability with a Ru complex. The resulting Ru-coordinated Azo-MOPs displayed high CO₂ capacity and high performances for catalyzing the methylation of amines with CO₂ under low pressure (0.5 MPa). In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Product Details of 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness was written by Abdeen, Sanofar;Salim, Nilshad;Mammadova, Najiba;Summers, Corey M.;Goldsmith-Pestana, Karen;McMahon-Pratt, Diane;Schultz, Peter G.;Horwich, Arthur L.;Chapman, Eli;Johnson, Steven M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Trypanosoma brucei are protozoan parasites that cause African sleeping sickness in humans (also known as Human African Trypanosomiasis-HAT). Without treatment, T. brucei infections are fatal. There is an urgent need for new therapeutic strategies as current drugs are toxic, have complex treatment regimens, and are becoming less effective owing to rising antibiotic resistance in parasites. The authors hypothesize that targeting the HSP60/10 chaperonin systems in T. brucei is a viable anti-trypanosomal strategy as parasites rely on these stress response elements for their development and survival. The authors recently discovered several hundred inhibitors of the prototypical HSP60/10 chaperonin system from Escherichia coli, termed GroEL/ES. One of the most potent GroEL/ES inhibitors the authors discovered was compound (I). While examining the PubChem database, the authors found that a related analog, 4-methyl-N-(4-(5-((4-methylphenyl)sulfonamido)benzo[d]oxazol-2-yl)phenyl)benzenesulfonamide (2e-p), exhibited cytotoxicity to Leishmania major promastigotes, which are trypanosomatids highly related to Trypanosoma brucei. Through initial counter-screening, the authors found that compounds (I) and 2e-p were also cytotoxic to Trypanosoma brucei parasites (EC₅₀ = 7.9 and 3.1 μM, resp.). These encouraging initial results prompted the authors to develop a library of inhibitor analogs and examine their anti-parasitic potential in vitro. Of the 49 new chaperonin inhibitors developed, 39% exhibit greater cytotoxicity to T. brucei parasites than parent compound (I). While many analogs exhibit moderate cytotoxicity to human liver and kidney cells, the authors identified mol. substructures to pursue for further medicinal chem. optimization to increase the therapeutic windows of this novel class of chaperonin-targeting anti-parasitic candidates. An intriguing finding from this study is that suramin, the first-line drug for treating early stage T. brucei infections, is also a potent inhibitor of GroEL/ES and HSP60/10 chaperonin systems. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stereospecific addition of carbon and nitrogen nucleophiles to dicyclopentadieneplatinum and -palladium complexes was written by Stille, John K.;Fox, Dale B.. And the article was included in Journal of the American Chemical Society in 1970.Computed Properties of C10H10Cl2Pt This article mentions the following:

The nucleophilic additions of acetylacetone, Et acetoacetate, diethyl malonate, or PhCH2NH2 to the double bond of dichloro(endo-dicyclopentadiene)platinum(II) and of thallous acetylacetone to dichloro(endo-dicyclopentadiene)palladium(II) produced platinum- and palladium-carbon σ-bonded complexes. The trans additions take place at the 5,6-double bond without skeletal rearrangement of the dicyclopentadiene moiety; the nucleophile is attached exo with the metal endo and coordinated to the 2,3-double bond. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Computed Properties of C10H10Cl2Pt).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C10H10Cl2Pt

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics