Month: February 2023

Potent Reductants via Electron-Primed Photoredox Catalysis: Unlocking Aryl Chlorides for Radical Coupling was written by Cowper, Nicholas G. W.;Chernowsky, Colleen P.;Williams, Oliver P.;Wickens, Zachary K.. And the article was included in Journal of the American Chemical Society in 2020.SDS of cas: 18437-66-6 This article mentions the following:

We describe a new catalytic strategy to transcend the energetic limitations of visible light by electrochem. priming a photocatalyst prior to excitation. This new catalytic system is able to productively engage aryl chlorides with reduction potentials hundreds of millivolts beyond the potential of Na⁰ in productive radical coupling reactions. The aryl radicals produced via this strategy can be leveraged for both carbon-carbon and carbon-heteroatom bond-forming reactions. Through direct comparison, we illustrate the reactivity and selectivity advantages of this approach relative to electrolysis and photoredox catalysis. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6SDS of cas: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea) was written by Ali, Abdelselam;Bliese, Marianne;Rasmussen, Jo-Anne M.;Sargent, Roger M.;Saubern, Simon;Sawutz, David G.;Wilkie, John S.;Winkler, David A.;Winzenberg, Kevin N.;Woodgate, Ruth C. J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Related Products of 75279-55-9 This article mentions the following:

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives, e.g., I, were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9Related Products of 75279-55-9).

2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 75279-55-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of gum acacia based magnetic nanocomposite adsorbent for wastewater treatment was written by Kulal, Prajwal;Krishnappa, Preetha B.;Badalamoole, Vishalakshi. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2022.Application In Synthesis of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

The present work reports development of a magnetic hydrogel adsorbent material based on the polysaccharide, gum acacia. This graft copolymer nanocomposite hydrogel of gum acacia and poly(3-chloro-2-hydroxypropylmethacrylate) has been made using microwave assisted technique. Magnetite nanoparticles have been generated by in-situ method and trapped in the network structure. The parent hydrogel and the hybrid nanocomposite were evaluated as adsorbents for sequestration of cationic dyes and metal ions from aqueous solution The FTIR, XRD, SEM, TGA, VSM and BET studies have been performed to characterize the samples with respect to their phys. and chem. structure, surface nature, thermal stability and magnetic property. The nanocomposite displayed super-paramagnetic nature owing to the presence of magnetite nanoparticles which also influenced the adsorption characteristics favorably as evident from the comparative studies performed with the non-magnetic parent gel. The nanocomposite exhibited larger surface area of 2.524 m²g^-1 compared to the parent hydrogel with surface area of 0.481 m²g^-1. The adsorption capability of the parent hydrogel towards methylene blue, rhodamine 6G, Cu(II) and Hg(II) are 224.4, 283.5, 282.4 and 275.3 mgg^-1, resp., were enhanced to 265.2, 344.4, 307.5 and 292.8 mgg^-1, resp., in the case of nanocomposite. The adsorption isotherm and kinetic studies indicated fit of Freundlich isotherm model and pseudo-second-order kinetic model, resp. The adsorption has been shown to be a multistep process involving boundary layer diffusion and intra-particle diffusion playing major roles. The thermodn. anal. manifested the adsorption as an exothermic and spontaneous process. The adsorption-desorption process studied in three cycles indicated excellent reusability characteristics of the nanocomposite making it a promising adsorbent material for wastewater treatment. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Application In Synthesis of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of different drying techniques on the volatile compounds, morphological characteristics and thermal stability of Stevia rebaudiana Bertoni leaf was written by Gasmalla, Mohammed Abdalbasit A.;Tessema, Habtamu A.;Alahmed, Kamal;Hua, Xiao;Liao, Xiangru;Yang, Ruijin. And the article was included in Tropical Journal of Pharmaceutical Research in 2017.Related Products of 3386-33-2 This article mentions the following:

Purpose: To examine the volatile compounds, thermal stability and morphol. characteristics of stevia (Stevia rebaudiana Bertoni) leaves after sun, oven and microwave drying. Methods: Gas chromatog.-mass spectrometry with a spectral anal. manager was used to sep. the volatile compounds Dried stevia leaf powder was characterized morphol. by SEM while thermal properties were determined by differential scanning calorimetry (DSC). Results: The plant material contained large amounts of spathulenol and caryophyllene oxide. The main compounds were 1-docosanol and hexanoic acid; trans-β-ionone, 5-methylundecane, 2,5,6- trimethyldecane, (+) spathulenol, propanoic acid and 1-chlorononadecane. The surface of the dried leaf powder varied with the treatment applied. Following microwave drying, the particles were even, regular, and compact while the sun- and oven dried particles resembled angular bricks. All samples exhibited a strong endothermic response, indicating stability up to 150 °C; from 150 to 200 °C, thermal decomposition occurred. Conclusion: Drying method has a significant effect on the structure, thermal stability and volatile compounds contents of stevia leaves. All drying methods examined in this study have potential applications in the preparation of stevia as a functional ingredient for the food and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Related Products of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of new 1,4- and 1,5-disubstituted N-ethyl acetate and N-α-butyro-γ-lactone alkylimidazole derivatives as N-acylhomoserine lactone analogs was written by Qiang, Zhang;Li, Si-Zhe;Queneau, Yves;Soulere, Laurent. And the article was included in Journal of Heterocyclic Chemistry in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:

New alkylimidazoles functionalized with a homoserine lactone or an alkyloxycarbonyl moiety was synthesized as N-acylhomoserine lactones (AHLs) analogs. The 1,4-disubstituted imidazole derivatives were prepared by alkylation of 4(5)-alkylimidazoles with α-bromo-γ-butyrolactone or Et α-bromoacetate. An alternative route was preferred for the synthesis of their 1,5-disubstituted counterparts based on the use of a N₁-protected alkylimidazole, its alkylation to an N₃-imidazolyl-α-acetate and deprotection to the desired 1,5-disubstituted esters and subsequent alkylation of the acetate moiety with cyclic ethylene sulfate followed by acid-catalyzed cyclization. The ability to modulate bacterial quorum sensing of all new compounds was compared to that of previously reported AHL analogs in which the amide bond is replaced by a heterocyclic group. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects was written by Mirabile, Salvatore;Vittorio, Serena;Paola Germano, Maria;Adornato, Ilenia;Ielo, Laura;Rapisarda, Antonio;Gitto, Rosaria;Pintus, Francesca;Fais, Antonella;De Luca, Laura. And the article was included in ChemMedChem in 2021.Electric Literature of C7H4ClNO4 This article mentions the following:

There is a considerable attention for the development of inhibitors of tyrosinase (TYR) as therapeutic strategy for the treatment of hyperpigmentation disorders in humans. Continuing in our efforts to identify TYR inhibitors, we describe the design, synthesis and pharmacophore exploration of new small mols. structurally characterized by the presence of the 4-fluorobenzylpiperazine moiety as key pharmacophoric feature for the inhibition of TYR from Agaricus bisporus (AbTYR). Our investigations resulted in the discovery of the competitive inhibitor [4-(4-fluorobenzyl)piperazin-1-yl]-(3-chloro-2-nitro-phenyl)methanone 26 (I, IC₅₀=0.18μM) that proved to be ∼100-fold more active than reference compound kojic acid (IC₅₀=17.76μM). Notably, compound 26 exerted antimelanogenic effect on B16F10 cells in absence of cytotoxicity. Docking anal. suggested its binding mode into AbTYR and into modelled human TYR. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Electric Literature of C7H4ClNO4).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of μ-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions was written by Dockendorff, Chris;Jin, Shujuan;Olsen, Madeline;Lautens, Mark;Coupal, Martin;Hodzic, Lejla;Spear, Nathan;Payza, Kemal;Walpole, Christopher;Tomaszewski, Miroslaw J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Application of 6834-42-0 This article mentions the following:

A series of 1-aminotetralin scaffolds was synthesized via metal-catalyzed ring-opening reactions of heterobicyclic alkenes. Small libraries of amides and amines were made using the amino group of each scaffold as a handle. Screening of these libraries against human opioid receptors led to the identification of (S)-(S)-I as a high-affinity selective μ ligand (IC₅₀ μ = 5 nM, κ = 707 nM, δ = 3,795 nM) displaying μ-agonist/antagonist properties due to its partial agonism (EC₅₀ = 2.6 μM; E _max = 18%). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel Ferulic Amide Ac6c Derivatives: Design, Synthesis, and Their Antipest Activity was written by Zhang, Renfeng;Guo, Shengxin;Deng, Peng;Wang, Ya;Dai, Ali;Wu, Jian. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Thirty-eight novel ferulic amide 1-aminocyclohexane carboxylic acid (Ac6c) derivatives D1-D19 (I) wherein R is CH₃-Ph, Cl-Ph, CF₃-Ph, etc.; and E1-E19 (II) wherein R is CH₃-Ph, Cl-Ph, CF₃-Ph, etc.; were designed and synthesized, and their antibacterial, antifungal, and insecticidal activities were tested. Most of the synthesized compounds displayed excellent activity against Xanthomonas oryzae pv. oryzae (Xoo), with EC₅₀ values ranging from 11.6 to 83.1μg/mL better than that of com. bismerthiazol (BMT, EC₅₀ = 84.3μg/mL), as well as much better performance compared to that of thiediazole copper (TDC, EC₅₀ = 137.8μg/mL). D6 (EC₅₀ = 17.3μg/mL), D19 (EC₅₀ = 29.4μg/mL), E3 (EC₅₀ = 29.7μg/mL), E9 (EC₅₀ = 27.0μg/mL), E10 (EC₅₀ = 18.6μg/mL), and E18 (EC₅₀ = 20.8μg/mL) showed much higher activity on Xanthomonas oryzae pv. oryzicola compared with BMT (EC₅₀ = 80.1μg/mL) and TDC (EC₅₀ = 124.7μg/mL). In relation to controlling the fungus, Rhizoctonia solani, E1, E10, and E13 had much lower EC₅₀ values of 0.005, 0.140, and 0.159μg/mL compared to hymexazol at 74.8μg/mL. Further in vivo experiments demonstrated that E6 and E12 controlled rice bacterial leaf blight disease better than BMT and TDC did. SEM studies revealed that E12 induced the Xoo cell membrane collapse. Moreover, D13 (73.7%), E5 (80.6%), and E10 (73.4%) also showed moderate activity against Plutella xylostella. These results indicated that the synthesized ferulic amide Ac6c derivatives showed promise as candidates for treating crop diseases. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Engineering of the chloroaniline-catabolic plasmid pDCA-1 and its potential for genetic bioaugmentation was written by Ke, Zhuang;Wang, Shen;Dai, Weixian;Jia, Weibin;Mu, Yang;Jiang, Jiandong;Chen, Kai. And the article was included in International Biodeterioration & Biodegradation in 2022.Formula: C13H9Cl3N2O This article mentions the following:

Plasmids disseminate pollutant-catabolic genes through horizontal transfer and contribute to the catabolic potential of the host microbial community. Genetic bioaugmentation of conjugative catabolic plasmids has recently been considered an effective and novel approach for long-term bioremediation of contaminated sites. In this study, we engineered an IncP-1β-2 subgroup plasmid pDCA-1 from Achromobacter sp. ANB-1 for its potential application in genetic bioaugmentation. A dcaA1A2B cluster responsible for the deamination of chloroaniline to chlorocatechol and a 1,2-dioxygenase gene (ccdC) for the ring cleavage of chlorocatechol were found to locate on the broad host range plasmid pDCA-1. Insertion of an amidase gene (phh or tccA2) at the accessory region of plasmid pDCA-1 greatly expanded its catabolic substrate spectrum from chloroaniline (3-chloroaniline and 3,4-dichloroaniline) to herbicides (linuron, propanil, propham, and chlorpropham), bacteriostatic agent (triclocarban), plant regulator (forchlorfenuron), and insecticide (diflubenzuron). Taking advantages of high-throughput cell sorting and 16S rRNA gene-based amplicon sequencing, we depicted the diversity of bacterial recipients for the engineered plasmid pDCA-1-gfp-phh in a soil bacterial consortium, showing an excellent conjugative transfer capacity of the pDCA-1 derivative to various Gram neg. and even pos. strains in natural environment. All in all, the engineered plasmid pDCA-1 had a great potential in genetic bioaugmentation of the sites contaminated with chloroanilines and their derivatives In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The influence of heterostructured TiO₂/ZnO nanomaterials for the removal of azo dye pollutant was written by Gnanasekaran, Lalitha;Priya, A. K.;Ghfar, Ayman A.;Sekar, Karthikeyan;Santhamoorthy, Madhappan;Arthi, M.;Soto-Moscoso, Matias. And the article was included in Chemosphere in 2022.Recommanded Product: 61-73-4 This article mentions the following:

In recent times, there has been an inspired research on combining semiconducting metal oxides for improved industrial applications. Significantly, wastewater removal is concerned and the researchers are finding new methodologies for removing azo dyes that possess a high level of carcinogenic effects. In this connection, this work investigates the photocatalytic activity of synthesized TiO₂/ZnO nanocomposite irradiated under UV and visible light. The application of the work involves the removal of methylene blue (MB) dye solution Initial work begins with the novel synthesis of TiO₂/ZnO coupled system by integrated sol-gel and thermal decomposition methods. Then, various characterization techniques brought out the existing properties of the prepared TiO₂/ZnO catalyst. The X-ray diffraction measurements showed the assorted tetragonal and hexagonal structures. The spherical shape mixed with hexagonal shaped particles were perceived via transmission electron microscopy (TEM). Besides, from photoluminescence spectrum (PL) results, the TiO₂/ZnO coupled system displayed slowing down of charge recombination, because of the intermediate states that helps in intensifying the photocatalytic activity. The dual absorption bands corresponding to UV region were deep-rooted from UV-vis spectroscopy. Further, the valuable application of the catalyst in removing methylene blue (MB) dye under both UV and visible light was carried out. The catalyst had displayed 90% of degradation within 40 min under UV light conditions. The other hand, visible light illumination of the catalyst provides divergent results as it possess lesser light absorption. Therefore, this catalyst was unable to yield visible light photocatalytic activity. Hence, this captivating research would bring the wastewater treatment progression using UV light. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics