Month: February 2023

Polyamide membranes with a ZIF-8@Tannic acid core-shell nanoparticles interlayer to enhance nanofiltration performance was written by Xia, Mengjiao;Zhang, Wentian;Xu, Yanchao;Lin, Hongjun;Jiao, Yang;Shen, Liguo;Li, Renjie;Zhang, Meijia;Hong, Huachang. And the article was included in Desalination in 2022.Safety of Trimesoylchloride This article mentions the following:

Polyamide nanofiltration membranes with an interlayer of either a plant polyphenol tannic acid (TA) coating to improve polyamide formation or zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (NPs) as a sacrificial template have been recently attracting great interest, although none has reported such a dual-functional interlayer. In this study, we demonstrated a facile and controllable one-pot synthesis of novel ZIF-8@TA core-shell NPs. Mixing Zn²⁺, Hmim, and TA in an aqueous solution could readily give rise to these NPs. Microscopy characterizations showed that composition and morphol. of NPs could be easily controlled by the amount of TA used. Comparing with the thin film nanocomposite (TFN) membrane prepared with ZIF-8 NPs as an interlayer, which had significant defects in its polyamide layer due to the aggregation of hydrophobic ZIF-8 NPs, the homogeneous and hydrophilic ZIF-8@TA NPs interlayered TFN membranes demonstrated intact polyamide layers. It was found that when 0.5 mg [email protected] NPs were used, the obtained TFN membrane showed a high water permeance of 20.7 L m^-2 h^-1 bar^-1 and Na₂SO₄ rejection of 96.6%, typically outperforming other interlayer-based PA membranes reported elsewhere. This work provided not only a novel interlayer material but also deep insights into design of high-performance polyamide membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Safety of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photoelectrochemical degradation of Methylene blue from solution using BiOBr/Bi₂S₃/TiO₂/GO photoanode was written by Nasiri, Maryam;Solaimany Nazar, Ali Reza;Frahadian, Mehrdad;Khosravi, Mohsen. And the article was included in Environmental Nanotechnology, Monitoring and Management in 2022.Computed Properties of C16H18ClN3S This article mentions the following:

The photoelectrochem. degradation of methylene blue (MB) dye through the stabilization of BiOBr/Bi₂S₃/TiO₂/GO nanocatalyst was examined The nanocatalysts were synthesized using the solvothermal method and the spin coating method was applied for the coating. In photoelectrochem. processes, the coated-FTO was used as the anode and the graphite as the cathode. An initial dye concentration of 10 mg/L, the initial pH level of 6, photocatalyst dosage of 0.5 g/L, and irradiation time of 90 min, were the optimal conditions for the photocatalytic degradation The exptl. value of degradation in MB was conceived to be 97.9%. The optimal conditions for the photoelectrochem. degradation of MB include the initial concentration of the dye of 17 mg/L, the initial pH level of 6, the number of coatings of 3 times, and the irradiation time of 90 min, and the exptl. value of 98.7% was obtained. The c.d. produced under optimal conditions was calculated and the effect of the light source and nitrogen gas on the efficiency was observed The possibility of recycling the photocatalyst up to 4 times in both suspended and stabilized forms, confirms the stability, repeatability, and optimal activity of the photocatalyst. The economic performance was also investigated. According to the trapping tests, holes and hydroxyl radicals were the main active species in the degradation process. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Computed Properties of C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and characterization of substituted poly(ferrocenylsilanes) and magnetic properties of their doped products was written by Liu, Yunyang;Tang, Hongding;Su, Xu;Chen, Xingguo;Li, Jun;Qin, Jingui;Zhang, Xixiang. And the article was included in Synthetic Metals in 2003.Related Products of 12083-92-0 This article mentions the following:

A series of substituted poly(ferrocenyl-silane)s were synthesized through transition-metal catalyzed ring-opening polymerization (ROP) of the corresponding [1]silaferrocenophanes. The structure of the polymers was studied using ¹H-NMR, FTIR, gel permeation chromatog. (GPC), and differential scanning calorimetry (DSC). The polymers formed ferromagnetic charge transfer complexes with tetracyanoethylene (TCNE). The the complexes showed paramagnetism below 110 K, as measured using SQUID. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Related Products of 12083-92-0).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 12083-92-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of several active N-chloro compounds from trichloroisocyanuric acid was written by Shiri, Azam;Khoramabadi-zad, Ahmad. And the article was included in Synthesis in 2009.Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

A very simple method for the preparation of several active N-chloro compounds that have extensive applications in organic synthesis, industry, and medicine was developed. Tetrachloroglycolurils, chloramine-T, N-chlorosaccharin, N-chlorosuccinimide, N-chlorophthalimide, N,N’-dichlorophenobarbital, and N,N’-dichlorobarbital were synthesized by chlorination with trichloroisocyanuric acid under mild reaction conditions at room temperature This method is clean, fast, and efficient; the yields are also good to excellent. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy was written by Ding, Junqiang;Sui, Dezhi;Liu, Mingqi;Su, Yuqing;Wang, Yang;Liu, Mengyang;Luo, Xiang;Liu, Xinrong;Deng, Yihui;Song, Yanzhi. And the article was included in Acta Biomaterialia in 2021.Recommanded Product: 1-Chlorooctadecane This article mentions the following:

Neutrophils and monocytes (N/Ms) are potential candidates for the delivery of therapeutic agents to the tumor microenvironment (TME) because of their tumor-accumulating nature. L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, resp., in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion. Therefore, we constructed a drug delivery nano-platform using N/Ms as vehicles. SA-stearic acid conjugate was synthesized and utilized to modify epirubicin-loaded liposomes (EPI-SL) for enhanced endocytosis of liposomes by circulating N/Ms. Cellular uptake studies showed that SA modification improved the accumulation of EPI in N/Ms and did not alter the inherent chemotaxis of N/Ms. In tumor-bearing mice, EPI-SL significantly improved the tumor-targeting efficiency and therapeutic efficacy of EPI compared to other preparations and even eradicated tumors because of the tumor-accumulating and inhibitory effects of N/Ms containing EPI-SL. Our research showed, for the first time, that as an N/M-based drug delivery platform, EPI-SL remedied the limited tumor targeting in the conventional EPR effect-based treatment strategy, contributing to the exploitation of a new drug delivery platform for cancer treatment. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

8-cyanobenzothiazinone analogs with potent antitubercular activity was written by Zhang, Gang;Sheng, Li;Hegde, Pooja;Li, Yan;Aldrich, Courtney C.. And the article was included in Medicinal Chemistry Research in 2021.Computed Properties of C8H3ClF3NO4 This article mentions the following:

8-Nitrobenzothiazinones (BTZs) exemplified by macozinone are a new class of antitubercular agents with exceptionally potent activity. The aryl nitro group has been considered indispensable for activity since this is bioactivated within mycobacteria by the flavoenzyme DprE1 to a reactive nitroso metabolite that covalently labels Cys387. However, the aryl nitro group is a potential liability with regards to safety, stability, and resistance. In this paper, we introduced a nitrile as a bioisosteric replacement of the nitro group, which we hypothesize can maintain a similar covalent mechanism of inhibition, but mitigate against the aforementioned concerns. 8-cyanobenzothiazinone 1d displayed potent antitubercular activity with an MIC of 130 nM and had an improved volume of distribution in mice that increased the intrinsic half-life by twofold compared to macozinone. Anal. of the C-2 substituent of 1d revealed similar structure-activity relationships as observed for macozinone. Overall, the results confirm the 8-nitro group of benzothiazinones can be successfully replaced with a nitrile to retain useful activity and favorable pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4Computed Properties of C8H3ClF3NO4).

2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H3ClF3NO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Air-stable nickel(II) borohydrides as prohydrides: Reactions with halocarbons and aerial carbon dioxide was written by Mani, Kalaikodikumaran;Pal, Parameswar;Anandababu, Karunanithi;Raje, Sakthi;Angamuthu, Raja. And the article was included in Inorganica Chimica Acta in 2021.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

Non-noble metal hydrides are highly attractive reagents owing to their involvement in the reactions of environmental and industrial interest. However, they are often cumbersome to isolate as a shelf-stable reagent. Herein, the authors have described the synthesis of non-noble metal hydrides by simple manual grinding of Ni(II)-chelates and NaBH₄ in open air at room temperature without using organic solvents. Two Ni(II) complexes of tetradentate N4 ligands, (L^NHCy = N,N’-bis(pyrid-2-ylmethyl)cyclohexanediamine) [(L^NHCy)Ni(MeCN)(H₂O)](ClO₄)₂ and [(tren)Ni(MeCN)₂](BPh₄)₂, were synthesized and their solid-state structures were confirmed by single crystal x-ray diffraction studies. Both the Ni complexes were manually ground with Na borohydride in open air to produce corresponding Ni(II)-borohydrides that were characterized using FTIR spectroscopy and powder x-ray diffraction techniques. Further, the borohydrides (prohydrides) activate the C-X bond in benzyl bromide, CDCl₃, trityl chloride and iodobenzene to yield toluene, CHDCl₂, triphenylmethane and benzene; the borohydrides reacted with trityl cation and air in MeCN solution to yield triphenylmethane and carbonate. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective Defluoroallylation of Trifluoromethylarenes was written by Luo, Chaosheng;Bandar, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2019.Computed Properties of C7H4ClF3O2S This article mentions the following:

The authors report a fluoride-initiated coupling reaction between trifluoromethylarenes and allylsilanes to access allylated α,α-difluorobenzylic compounds This method’s utility is demonstrated through a 30 mmol scale reaction, a sequential allylation/derivatization protocol and multiple examples of site-selective trifluoromethylarene allylation. Initial mechanistic studies suggest a base-induced single electron transfer pathway is responsible for the high efficiency and selectivity of this novel C-F substitution process. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Computed Properties of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metalation and halogen-metal interconversion reactions of some halogenated phenyl ethers was written by Langham, Wright;Brewster, R. Q.;Gilman, Henry. And the article was included in Journal of the American Chemical Society in 1941.Electric Literature of C8H7ClO3 This article mentions the following:

The reactions of certain halogen derivatives of Ph₂O with MeLi, BuLi and PhLi have been studied. When the halogen is I or Br, halogen-metal interconversion is found to be the predominant reaction. IC₆H₄OPh undergo interconversion more readily than the Br derivatives and the Cl derivatives are essentially not affected. During long periods of reaction or upon refluxing in ether, p-Br and p-Cl derivatives are metalated by MeLi, BuLi and PhLi; under the same conditions the p-I derivative is metalated in reactions with BuLi and PhLi. In general 0.01 mol of the ether was reacted with 0.02 mol of the Li derivative at 26° for 0.25 h. 2-IC₆H₄OPh with BuLi gives 79%, PhLi 56% (79% at 18-20° for 24 h.), MeLi (0.1 mol) 14% of 2-PhOC₆H₄CO₂H after carbonation of the reaction product. 3-IC₆H₄OPh with BuLi gives 75% or with 0.1 mol PhLi 37% of 3-PhOC₆H₄CO₂H. 4-IC₆H₄OPh (I) with BuLi gives 93% or 0.1 mol of PhLi gives 33% of 4-PhOC₆H₄CO₂H; 0.02 mol I and 0.1 mol of BuLi at 20-2° for 26 h. or 0.02 mol I and 0.02 mol of PhLi at 34° for 15 h. give 30 or 32% of 2,5-(PhO)-IC₆H₃CO₂H. 4-IC₆H₄OC₆H₄OMe-4 with 0.2 mol BuLi or 0.01 mol of PhLi gives 61 or 47% of 4-(4′-MeOC₆H₄O)-C₆H₄CO₂H. 2-BrC₆H₄OPh and BuLi give 65% of 2-PhOC₆H₄CO₂H. 4-BrC₆H₄OPh with 0.01 mol of BuLi for 0.033 h. or 0.02 mol of PrLi at 26° for 0.083 h. gives 36 or 80% of 4-PhOC₆H₄CO₂H; 0.1 mol of PhLi gives 7% of 2,5-(PhO)BrC₆H₃CO₂H; 0.15 mol ether and 0.8 mol PhLi at 20° for 24 h. or 0.01 mol of ether and 0.01 mol of MeLi for 24 h. at 20° give 35 and 14% of 2,5-(PhO)-BrC₆H₃CO₂H. 3,4-Br(MeO)C₆H₃OPh gives with BuLi 66% of 2,5-MeO(PhO)C₆H₃CO₂H. 2-ClC₆H₄OPh does not react with MeLi at 20° after 24 h. 2,5-(PhO)ClC₆H₃CO₂H results in 16, 23, 36 and 14% yields from 0.005, 0.015, 0.02 or 0.01 mol of 4-ClC₆H₄OPh with 0.008 mol BuLi at 26° in 0.25 h., 0.02 mol BuLi at 34° in 10 h., 0.01 mol of PhLi at 20° in 26 h. or 0.01 mol of MeLi at 20° in 24 h. Many comments are given on the individual experiments p-FC₆H₄OMe (0.03 mol) and 0.05 mol MeLi (all experiments at 34° for 14 h.) give 17.7% of 2,5-(MeO)FC₆H₃CO₂H and 38.5% unreacted F compound p-ClC₆H₄OMe (0.03 mol) gives 21.6% of 2,5-(MeO)ClC₆H₃CO₂H and 57% unreacted Cl derivative p-BrC₆H₄OMe (0.02 mol) and 0.03 mol MeLi give 21.7% of 2,5-(MeO)BrC₆H₃CO₂H; in another experiment there resulted 16% of acid and 50% of unreacted Br compound p-IC₆H₄OMe (0.03 mol) and 0.05 mol of MeLi give 13.1% of 4-MeOC₆H₄CO₂H and 48.6% of p-MeC₆H₄OMe; in a 2nd experiment the yields were 5 and 52%, resp. o-ClC₆H₄OMe does not react with MeLi. o-BrC₆H₄OMe gives 16.6% of 2-MeOC₆H₄CO₂H and 43.5% of o-MeC₆H₄OMe. o-IC₆H₄OMe (0.013 mol) and 0.03 mol of MeLi give 12.5% of 2-MeOC₆H₄CO₂H and 75% of o-MeC₆H₄OMe. m-BrC₆H₄OMe (0.02 mol) and 0.03 mol of MeLi give 0.7 g. of an acidic gum, 13% of m-MeC₆H₄OMe and 0.43 g. of a product b₉ 79-81°. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Electric Literature of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective N-Monomethylation of Amines and Nitroarenes using Methanol over an Encapsulated Iridium Nanocatalyst was written by Fu, Aixiao;Liu, Qiang;Jiang, Mingxiang;Xu, Guoqiang. And the article was included in Asian Journal of Organic Chemistry in 2019.COA of Formula: C8H10ClN This article mentions the following:

A highly selective N-monomethylation of aniline and nitrobenzene using methanol as methylating reagent was achieved with high efficiency when using an encapsulated iridium nanocatalyst. A wide range of amines and nitro compounds reacted well in the established catalytic system with moderate to excellent product yields and good functional group tolerance. The transfer hydrogenation and successive cyclization coupling reaction of ortho-phenylenediamine with methanol to afford benzimidazole and N-methylbenzimidazole was also efficiently realized under moderate reaction conditions. Recycling experiments showed that the iridium nanocatalyst had a good stability without obvious activity loss. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics