Month: February 2023

Synthesis and SAR of 5-, 6-, 7- and 8-Aza Analogues of 3-Aryl-4-hydroxyquinolin-2(1H)-one as NMDA/Glycine Site Antagonists was written by Zhou, Z.-L.;Navratil, J. M.;Cai, S. X.;Whittemore, E. R.;Espitia, S. A.;Hawkinson, J. E.;Tran, M.;Woodward, R. M.;Weber, E.;Keana, J. F. W.. And the article was included in Bioorganic & Medicinal Chemistry in 2001.COA of Formula: C9H9ClO2 This article mentions the following:

A series of 5-, 6-, 7- and 8-aza analogs of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [³H]5,7-dichlorokynurenic acid ([³H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiol. assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (I) is the most potent antagonist, having an IC₅₀ value of 110 nM in [³H]DCKA binding and a K_b of 11 nM in the electrophysiol. assay. Compound I is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED₅₀=2.3 mg/kg, IP). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile synthesis of CdO-ZnO heterojunction photocatalyst for rapid removal of organic contaminants from water using visible light was written by Warshagha, Murad Z. A.;Muneer, Mohammad. And the article was included in Environmental Nanotechnology, Monitoring and Management in 2022.Related Products of 61-73-4 This article mentions the following:

The synthesis of an efficient photocatalyst for removing organic contaminants in the water is of major importance for researchers working in heterogeneous photocatalysis. To do this, we provide the co-precipitation approach for synthesizing heterojunction nanocomposite (CdO-ZnO). Standard anal. techniques were used to characterize the synthesized components. According to the XRD and DRS results, a composite of ZnO and CdO was effectively synthesized with a shift of λ^max towards the higher wavelength. SEM pictures reveal well-decorated oval-shaped CdO nanoparticles with hexagonal ZnO particle morphol. Under visible light irradiation, the as-prepared CdO-ZnO nanocomposite demonstrated very efficient photocatalytic performance as measured by the decomposition of RhB, MB, paracetamol, and ciprofloxacin in an aqueous solution The photo-mineralization of MB and RhB over the most active CZ-3 catalyst was also assessed by measuring the decrease in TOC (total organic carbon) content over time when exposed to visible light. The breakdown of paracetamol produces no hazardous byproducts, according to high-performance liquid chromatog. (HPLC) study. The photocatalytic process appears to be dominated by ^·OH and h⁺, according to the radical scavenger tests. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Related Products of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors was written by Guo, Xiaoke;Yang, Qian;Xu, Jing;Zhang, Li;Chu, Hongxi;Yu, Peng;Zhu, Yingying;Wei, Jinglian;Chen, Weilin;Zhang, Yaozhong;Zhang, Xiaojin;Sun, Haopeng;Tang, Yiqun;You, Qidong. And the article was included in Bioorganic & Medicinal Chemistry in 2013.COA of Formula: C10H13ClO3S This article mentions the following:

Atrial fibrillation (AF) is one of the common arrhythmias that threaten human health. Kv1.5 potassium channel is reported as an efficacious and safe target for the treatment of AF. In this paper, we designed and synthesized three series of compounds through modifying the lead compound RH01617 that was screened out by the pharmacophore model we reported earlier. All of the compounds were evaluated by the whole-patch lamp technol. and most of them possessed potent inhibitory activities against Kv1.5. Two of the compounds were evaluated for the target selectivity as well as the pharmacodynamic effects in an isolated rat model. Due to the promising pharmacol. behavior, one compound deserves further pharmacodynamic and pharmacokinetic evaluations. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3COA of Formula: C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rh(III)-catalyzed oxidative C-H activation/domino annulation of anilines with 1,3-diynes: a rapid access to blue-emitting tricyclic N,O-heteroaromatics was written by Qian, Shengyou;Pu, Xingwen;Chang, Guanjun;Huang, Ying;Yang, Yudong. And the article was included in Organic Letters in 2020.Safety of tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Disclosed herein is a rhodium-catalyzed oxidative C-H activation/domino annulation of N-Boc-anilines with 1,3-diynes for the construction of tricyclic N,O-heteroaromatics This reaction features easily available substrates, mild reaction conditions, high regioselectivity, mono/diannulation selectivity, and intra/intermol. annulation selectivity. Moreover, this synthetic protocol enables the rapid assembly of a library of blue-emitting mols. with high quantum yields, among of which two fluorophores with pure blue-emission in toluene are discovered. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Safety of tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metal-free directed C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines was written by Wu, Gaorong;Xu, Xiaobo;Wang, Shuai;Chen, Lu;Pang, Binghan;Ma, Tao;Ji, Yafei. And the article was included in Chinese Chemical Letters in 2022.Reference of 620-19-9 This article mentions the following:

A novel method for metal-free C-H pyridine-directed borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines with BBr₃ has been reported, affording complexes R¹C₆H₃(Bpin)-2-XR²-5-FC₅H₄N-2 (X = N, CH; R¹ = H, alkyl, halo; R² = H, Me). The 5-fluoropyridine directed borylation reaction exhibited high efficiency and site exclusivity. The useful protocol could be executed on a gram-scale easily and the borylated products showed good derivatization applications. Moreover, the practicality of the strategy was expanded by the fact that the directing group could be removed in an acceptable yield. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Reference of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors was written by Si, Dongjuan;Luo, Huijuan;Zhang, Xiaomeng;Yang, Kundi;Wen, Hongmei;Li, Wei;Liu, Jian. And the article was included in Bioorganic Chemistry in 2021.Application In Synthesis of 2,5-Difluorophenylacetyl chloride This article mentions the following:

Inhibition of the interactions of the tumor suppressor protein p53 with its neg. regulators MDM2 in vitro and in vivo, representing a valuable therapeutic strategy for cancer treatment. The natural product chalcone exhibited moderate inhibitory activity against MDM2, thus based on the binding mode between chalcone and MDM2, a hit unsaturated pyrrolidone scaffold was obtained through virtual screening. Several unsaturated pyrrolidone derivatives were synthesized and biol. evaluated. As a result, because the three critical hydrophobic pockets of MDM2 were occupied by the substituted-Ph linked at the pyrrolidone fragment, compound I demonstrated good binding affinity with the MDM2. Addnl., compound I also showed excellent antitumor activity and selectivity, and no cytotoxicity against normal cells in vitro. The further antitumor mechanism studies were indicated that compound I could successfully induce the activation of p53 and corresponding downstream p21 proteins, thus successfully causing HCT116 cell cycle arrest in the G1/M phase and apoptosis. Thus, the novel unsaturated pyrrolidone p53-MDM2 inhibitors could be developed as novel antitumor agents. In the experiment, the researchers used many compounds, for example, 2,5-Difluorophenylacetyl chloride (cas: 157033-23-3Application In Synthesis of 2,5-Difluorophenylacetyl chloride).

2,5-Difluorophenylacetyl chloride (cas: 157033-23-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 2,5-Difluorophenylacetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors was written by Goldberg, Frederick W.;Birch, Alan M.;Leach, Andrew G.;Groombridge, Sam D.;Snelson, Wendy L.;Gutierrez, Pablo Morentin;Hammond, Clare D.;Birtles, Susan;Buckett, Linda K.. And the article was included in MedChemComm in 2013.Computed Properties of C9H9ClO3 This article mentions the following:

A series of neutral DGAT1 inhibitors with good potency and pharmacokinetics (PK) has been designed by modification of an acidic startpoint. This was achieved by selecting the acid with the highest ligand lipophilicity efficiency (LLE) and replacing the acid with neutral isosteres. PK properties (F_abs) were then improved by removing the sidechain to reduce mol. weight and polar surface area (PSA). Compound 13 has shown good cross-species PK, with pre-clin. efficacy and PK/PD relationships comparable to those previously described for acidic inhibitors. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Computed Properties of C9H9ClO3).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Oxidative Carbonylation of Aromatic C-H Bonds of N-Alkylanilines with CO and Alcohols for the Synthesis of o-Aminobenzoates was written by Chen, Ming;Ren, Zhi-Hui;Wang, Yao-Yu;Guan, Zheng-Hui. And the article was included in Journal of Organic Chemistry in 2015.Reference of 18437-66-6 This article mentions the following:

A Pd(II)-catalyzed C-H monocarbonylation of N-alkylanilines for the synthesis of o-aminobenzoates has been developed. Various aliphatic alcs. and phenol were tolerated in the reaction to afford the corresponding o-aminobenzoates in good yields under mild balloon pressure of CO. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Mediated One-pot Synthesis of Oxygen-Based Heterocycles from 2-Hydroxyphenyl-Substituted para-Quinone Methides was written by Singh, Gurdeep;Kumar, Suresh;Chowdhury, Arjun;Vijaya Anand, Ramasamy. And the article was included in Journal of Organic Chemistry in 2019.Reference of 6834-42-0 This article mentions the following:

One-pot synthesis of oxygen-containing heterocycles has been achieved through alkylation/acylation of 2-hydroxyphenyl-substituted para-quinone methides followed by an intramol. 1,6-conjugate addition/cyclization and oxidation sequence. This protocol provides access to a wide range of oxygen-based heterocycles, such as 2,3-disubstituted benzo[b]furans, 2,3-dihydrobenzofurans and diaryl-substituted coumarin derivatives in moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium(II)-Catalyzed meta-C-H Olefination: Constructing Multisubstituted Arenes through Homo-Diolefination and Sequential Hetero-Diolefination was written by Bera, Milan;Maji, Arun;Sahoo, Santosh K.;Maiti, Debabrata. And the article was included in Angewandte Chemie, International Edition in 2015.COA of Formula: C7H5ClF2 This article mentions the following:

The palladium-catalyzed synthesis of divinylbenzenes, e.g., I, by meta-C-H olefination of sulfonate-based arenes was reported. Successful sequential olefinations in a position-selective manner provided a novel route for the synthesis of hetero-dialkenylated products, which are difficult to access using conventional methods. Addnl., 1,3,5-trialkenylated compounds can be generated upon successful removal of the directing group. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics