Month: February 2023

Influence of mass ratio and calcination temperature on physical and photoelectrochemical properties of ZnFe-layered double oxide/cobalt oxide heterojunction semiconductor for dye degradation applications was written by Zhang, Yufei;Zheng, Junjie;Nan, Jiejie;Gai, Chengjie;Shao, Qian;Murugadoss, Vignesh;Maganti, Srihari;Naik, Nithesh;Algadi, Hassan;Huang, Mina;Xu, Ben Bin;Guo, Zhanhu. And the article was included in Particuology in 2023.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

A visible light-active photoelectrocatalyst, ZnFe-layered double oxide (LDO)/cobalt(II,III) oxide (Co₃O₄) composites were obtained by calcining the Co loaded ZnFe-layered double hydroxide (LDH) prepared by a hydrothermal and microwave hydrothermal method. The morphol. studies revealed that the ZnFe-LDO/Co₃O₄ composites exhibited a flower-like structure comprising Co₃O₄ nanowires and ZnFe-LDO nanosheets. Further, when the mass ratio of Co(NO₃)₂.6H₂O/LDH was 1:1.8 and the calcination temperature was 550掳C, the ZnFe-LDO/Co₃O₄ composite exhibited 93.3% degradation efficiency for methylene blue (MB) at the applied voltage of 1.0 V under visible light after 3 h. Furthermore, the Mott-Schottky model experiments showed that the formation of a p-n heterojunction between ZnFe-LDO and Co₃O₄ could effectively inhibit the recombination of electrons and holes in the photoelectrocatalytic process. Meanwhile, free radical scavenging experiments showed that the active radicals of .OH played an important role in the degradation of MB. Therefore, the photoelectrocatalytic effect of ZnFe-LDO/Co₃O₄ provides a simple and effective strategy for the removal of organic pollutants. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Constructing chemical stable 4-carboxyl-quinoline linked covalent organic frameworks via Doebner reaction for nanofiltration was written by Yang, Yongliang;Yu, Ling;Chu, Tiancheng;Niu, Hongyun;Wang, Jun;Cai, Yaqi. And the article was included in Nature Communications in 2022.Quality Control of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

Covalent linkages are the key component of covalent organic frameworks (COFs). The development of stable and functional linkages is essential to expand the COFs family and broaden their application prospects. In this work, we report the synthesis of crystalline and chem. stable 4-carboxyl-quinoline linked COFs (QL-COFs) via Doebner reactions in both one-pot (OP) and post-synthetic modification (PSM) methods. Both methods can be universally applied to most of the reported imine COFs family via bottom-up construction or linkage conversion. Owing to the contractive pore size, more hydrophilic structure and better chem. stability than the conventional imine COFs endowed by 4-carboxyl-quinoline linkage, QL-COFs are supposed to possess a wider application range. We further demonstrate the nanofiltration membrane (NFM) based on QL-COF exhibited a desirable separation capacity with high rejection for small dye mols. (> 90%), high water permeance (850 L m^-2 h^-1 MPa^-1) and tolerance of extreme conditions (1 M HCl/NaOH), which were benefitted from the enhanced properties of QL-COFs. Addnl., efficient ion sieving properties were also achieved by QL-COF membrane. We anticipate that this work opens up a way for the construction of robust and functional COFs materials for practical applications. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Quality Control of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium-Calcium Exchanger: Potential Therapeutics for Type II Diabetes was written by Pei, Yazhong;Lilly, Michael J.;Owen, David J.;D’Souza, Lawrence J.;Tang, Xiao-Qing;Yu, Jinghua;Nazarbaghi, Ramina;Hunter, Andrew;Anderson, Christen M.;Glasco, Susan;Ede, Nicholas J.;James, Ian W.;Maitra, Uday;Chandrasekaran, S.;Moos, Walter H.;Ghosh, Soumitra S.. And the article was included in Journal of Organic Chemistry in 2003.Computed Properties of C11H14ClNO2 This article mentions the following:

Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurol., and retinal complications. While several drugs are currently prescribed to treat type II diabetes, their efficacy is limited by mechanism-related side effects (weight gain, hypoglycemia, gastrointestinal distress), inadequate efficacy for use as monotherapy, and the development of tolerance to the agents. Consequently, combination therapies are frequently employed to effectively regulate blood glucose levels. We have focused on the mitochondrial sodium-calcium exchanger (mNCE) as a novel target for diabetes drug discovery. We have proposed that inhibition of the mNCE can be used to regulate calcium flux across the mitochondrial membrane, thereby enhancing mitochondrial oxidative metabolism, which in turn enhances glucose-stimulated insulin secretion (GSIS) in the pancreatic 尾-cell. In this paper, we report the facile synthesis of benzothiazepines, e.g., I, and derivatives by S-alkylation using 2-aminobenzhydrols. The syntheses of other bicyclic analogs based on benzothiazepine, benzothiazecine, benzodiazecine, and benzodiazepine templates are also described. These compounds have been evaluated for their inhibition of mNCE activity, and the results from the structure-activity relationship (SAR) studies are discussed. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Computed Properties of C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives was written by Bagul, Suresh D.;Rajput, Jamatsing D.;Tadavi, Samina K.;Bendre, Ratnamala S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 777-44-6 This article mentions the following:

Abstract: Sulfonamides have enormous importance in biol. sciences. In the present investigation, the fundamental energetic group, hydrazide-based sulfonamide, has been incorporated into a naturally occurring phenolic monoterpenoid, carvacrol (5-isopropyl-2-methylphenol) moiety, with the aim of combining the active groups to generate more potent antimicrobial and anti-oxidant agents. Series of hydrazide-based sulfonamide derivatives (IV a-g) have been synthesized and characterized by modern sophisticated techniques such as ¹H NMR, ¹³C NMR and LC-MS. The newly synthesized derivatives were screened for their antimicrobial activities against three fungal (Aspergillus niger, A. flavus and A. fumigatus) and three bacterial (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) species, of which compounds IVc and IVd were found to have good antifungal activity and compounds IVd and IVg exhibited decent antibacterial activities. Antioxidant activity was performed by DPPH radical scavenging assay. Compound IVd has been found to be more active in comparison to standard ascorbic acid and compounds IVa, IVb, and IVc demonstrated excellent antioxidant activity. Graphical Abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Exploring ibuprofen derivatives as 伪-glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies was written by Daud, Saima;Abid, Obaid-ur-Rahman;Sardar, Asma;Abdullah, Shawana;Shahid, Wardah;Ashraf, Muhammad;Ejaz, Syeda Abida;Saeed, Amna;Shah, Basit Ali;Niaz, Basit. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2022.Synthetic Route of C7H3Cl2NS This article mentions the following:

This study reports the synthesis of a series of ibuprofen derivatives, including thiosemicarbazides 4a-f, 1,3,4-oxadiazoles 5a-f, 1,3,4-thiadiazoles 6a-f, 1,2,4-triazoles 7a-f, and their S-alkylated derivatives 8a-d. All of the newly synthesized derivatives were analyzed using 1H NMR, 13C NMR spectroscopy, and high-resolution mass spectra (electron ionization) spectrometry. These synthetic mols. were examined for their in vitro baking yeast 伪-glucosidase and soybean 15-lipoxygenase (15-LOX) inhibition and cell viability studies. The results revealed that the compounds N-(3,4-dichlorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5f (IC50 3.05 卤 1.23 渭M) and N-(3-fluorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5b (IC50 3.12 卤 1.21 渭M) were the most potent with respect to the 伪-glucosidase enzyme while in case of 15-LOX, the compound 4-(2,4-dichlorophenyl)-1-[2-(4-isobutylphenyl)propanoyl]thiosemicarbazide 4e showed potent inhibition with an IC50 value of 55.41 卤 0.41 渭M. All these compounds were found least toxic by displaying a blood mononuclear cell viability value of 69.2%-97.8% by the MTT assay compared to the standards when assayed at 0.25 mM concentration Mol. docking analyses were conducted to evaluate the inhibition profiles of these derivatives against the said enzymes and the data supported the in vitro profiles. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli was written by Chan, Michael;Lao, Fitzgerald S.;Chu, Paul J.;Shpigelman, Jonathan;Yao, Shiyin;Nan, Jason;Sato-Kaneko, Fumi;Li, Vicky;Hayashi, Tomoko;Corr, Maripat;Carson, Dennis A.;Cottam, Howard B.;Shukla, Nikunj M.. And the article was included in Journal of Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:

Agents that safely induce, enhance, or sustain multiple innate immune signaling pathways could be developed as potent vaccine adjuvants or coadjuvants. Using high-throughput screens with cell-based nuclear factor 魏B (NF-魏B) and interferon stimulating response element (ISRE) reporter assays, we identified a bis-aryl sulfonamide bearing compound 1 that demonstrated sustained NF-魏B and ISRE activation after a primary stimulus with lipopolysaccharide or interferon-伪, resp. Here, we present systematic structure-activity relationship (SAR) studies on the two Ph rings and amide nitrogen of the sulfonamide group of compound 1 focused toward identification of affinity probes. The murine vaccination studies showed that compounds 1 and 33 when used as coadjuvants with monophosphoryl lipid A (MPLA) showed significant enhancement in antigen ovalbumin-specific Ig responses compared to MPLA alone. SAR studies pointed to the sites on the scaffold that can tolerate the introduction of aryl azide, biotin, and fluorescent rhodamine substituents to obtain several affinity and photoaffinity probes which will be utilized in concert for future target identification and mechanism of action studies. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Category: chlorides-buliding-blocks).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enol-keto tautomerism of 伪-ketophosphonates was written by Tam, Coretta C.;Mattocks, Karen L.;Tishler, Max. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 1981.HPLC of Formula: 6834-42-0 This article mentions the following:

R¹CHR²COP(O)(OEt)₂ (I; R¹ = H, R² = Me, CMe₃, Ph, o-, m-, p-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, p-O₂NC₆H₄; R¹ = R² = Me) were prepared in 60-90% yield by reaction of R¹CHR²COCl with P(OEt)₃; the keto-enol tautomerism of I was studied by proton and P NMR and IR and the FeCl₃ test. Aliphatic I existed largely in the keto tautomeric forms, with only a small amount of enol forms present; however, aromatic I enolized extensively. Reaction of I (R¹ = H, R² = p-MeOC₆H₄) with CH₂N₂ gave a mixture of O-methylation and carbene insertion products; similar reaction of I (R¹ = R² = Me) gave only carbene insertion products. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0HPLC of Formula: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Improvement of mechanical properties and heat distortion temperature of polylactic acid by highly aromatic hyperbranched polyamide was written by Sun, Jianjian;Huang, Yansong;Jin, Yujuan;Tian, Huafeng;Men, Shuang. And the article was included in Journal of Applied Polymer Science in 2022.HPLC of Formula: 4422-95-1 This article mentions the following:

The highly aromatic hyperbranched polyamide (HBPA) was synthesized and used as a modifier in order to enhance the phys. performance of polylactic acid (PLA). The results showed that compared to the neat PLA, the tensile strength of the PLA/HBPA blends increased by 41.8%; fracture energy increased by 42.8% when the content of HBPA was 1.0 phr. The addition of HBPA can significantly improve the thermal deformation temperature of PLA. The polarized optical microscope images suggested that HBPA can act as a nucleating agent for PLA during the isothermal crystallization This research indicated HBPA exhibits excellent reinforcing effect for PLA, due to the formation of hydrogen bonds and/or chem. crosslinking between HBPA and PLA. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1HPLC of Formula: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Continuous Dermal Exposure to Triclocarban Perturbs the Homeostasis of Liver-Gut Axis in Mice: Insights from Metabolic Interactions and Microbiome Shifts was written by Zhang, Hongna;Liang, Yanshan;Wu, Pengfei;Shi, Xianru;Zhang, Guodong;Cai, Zongwei. And the article was included in Environmental Science & Technology in 2021.COA of Formula: C13H9Cl3N2O This article mentions the following:

Humans are constantly exposed to antimicrobial triclocarban (TCC) via direct skin contact with personal care and consumer products, but the safety of long-term dermal exposure to TCC remains largely unknown. Herein, we used a mouse model to evaluate the potential health risks from the continuous dermal application of TCC at human-relevant concentrations After percutaneous absorption, TCC circulated in the bloodstream and largely entered the liver-gut axis for metabolic disposition. Nontargeted metabolomics approach revealed that TCC exposure perturbed mouse liver homeostasis, as evidenced by the increased oxidative stress and impaired methylation capacity, leading to oxidative damage and enhancement of upstream glycolysis and folate-dependent one-carbon metabolism Meanwhile, TCC was transformed in the liver through hydroxylation, dechlorination, methylation, glucuronidation, sulfation, and glutathione conjugation. TCC-derived xenobiotics were subsequently excreted into the gut, and glucuronide and sulfate metabolites could be further deconjugated by the gut microbiota into their active free forms. In addition, microbial community anal. showed that the composition of gut microbiome was altered in response to TCC exposure, indicating the perturbation of gut homeostasis. Together, through tracking the xenobiotic-biol. interactions in vivo, this study provides novel insights into the underlying impacts of dermally absorbed TCC on the liver and gut microenvironments. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2COA of Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recyclable NiO/sepiolite as adsorbent to remove organic dye and its regeneration was written by Gao, Shu;Wang, Dahua;Huang, Zhi;Su, Chengyuan;Chen, Menglin;Lin, Xiangfeng. And the article was included in Scientific Reports in 2022.Recommanded Product: 61-73-4 This article mentions the following:

In this study, the impregnation synthesis of NiO/sepiolite and its application for dye removal during wastewater treatment is introduced. The NiO/sepiolite materials act as an adsorbent/catalyst. It comprises a unique combination of adsorption and high-temperature gas flow regeneration (the NiO/sepiolite acts as a catalyst at this stage, using regeneration rate as evaluation index of catalytic activity of NiO/sepiolite) in a single unit, in which the NiO/sepiolite was regenerated and reused for the next round adsorption of dye. An aqueous solution of methylene blue was used to evaluate the adsorption and regeneration performance of the adsorbent/catalyst. The regeneration rate reached 74% when the reaction time and temperature were 7 min and 350掳C, resp. The effects of the regeneration temperature and volume fraction of O2 on the regeneration rate were investigated. And the regeneration reaction kinetics was provided. The combination of adsorptive and catalytic properties in the NiO/sepiolite composites received interesting results for removing refractory biodegradable organic pollutants. This work provides new insights for the removal of dye from wastewater using Ni catalysts supported on natural low-cost clay. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics