Month: February 2023

Cyclopropanation via the Michael addition was written by Nishiyama, Kazuyoshi;Oda, Junichi;Inouye, Yuzo. And the article was included in Bulletin of the Institute for Chemical Research, Kyoto University in 1974.Application of 7476-66-6 This article mentions the following:

RCH2R1 (R = Ph, R1 = CN) and CH2:C[OP(O)(OMe)2]CO2Me (I) in DMF containing NaH gave cis- and trans-II (R = Ph, R1 = CN) via the RC-R1CH2CH[OP(O)(OMe)2]CO2Me (R = Ph, R1 = CN) intermediate which was formed from the initial Michael adduct, RCHR1CH2C-[OP(O)(OMe)2]CO2Me. The reaction of PhCH2CO2Me with I to give II (R = Ph, R1 = CO2Me) proceeded by the same mechanism. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Calcareous deposit formation under cathodic polarization and marine biocalcifying bacterial activity was written by Colin, Beatrice;Vincent, Julia;Koziorowszki, Lilla;Frein, Aurore;Lanneluc, Isabelle;Sabot, Rene;Refait, Philippe;Sable, Sophie;Jeannin, Marc. And the article was included in Bioelectrochemistry in 2022.COA of Formula: C16H18ClN3S This article mentions the following:

CaCO₃ precipitation can occur through bacterial activity (biomineralization) but can also take place in abiotic conditions in seawater at a steel surface under cathodic polarization. In this work, we used two biocalcifying bacterial strains: Pseudoalteromonas sp. and Virgibacillus halodenitrificans isolated in a previous work from marine environment for their ability to induce CaCO₃ precipitation Motility experiments were performed to evaluate the bacterial behavior in the absence or presence of an applied elec. current of -600 μA/cm² in a solid medium. As no alteration of bacterial growth or CaCO₃ crystal formation were observed, we studied both strains in liquid cultures at different applied currents densities: -100, -200 and -600 μA/cm². The deposits formed on the cathode surface were characterized by μ-Raman spectroscopy and X-ray diffraction. The strain ability to biocalcify in the presence of elec. current, in the liquid medium, was evaluated by monitoring bacterial growth, pH evolution, CaCO₃ production and metabolic characterization for 7 days. Our results show that neither bacterial growth, enzymic pathways or CaCO₃ production were altered by the elec. current. Moreover, bacterial activity modified drastically the nature of the compounds formed on the cathode surface. It favored Mg-containing calcite, hindering the formation of both aragonite and brucite. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4COA of Formula: C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Conversion of thiols into sulfonyl halogenides under aerobic and metal-free conditions was written by Jereb, Marjan;Hribernik, Luka. And the article was included in Green Chemistry in 2017.Electric Literature of C7H4ClF3O2S This article mentions the following:

An environmentally benign, metal-free synthesis of sulfonyl chlorides and bromides from thiols in the presence of ammonium nitrate, an aqueous solution of HCl and HBr and oxygen as a terminal oxidant was developed. The reactivity of various substituted thiophenols, benzylic-, aliphatic- and heteroaromatic thiols was examined Ammonium nitrate served as a source of nitrogen oxides (NO/NO₂), which are the crucial players in a redox-catalytic cycle. Sulfonyl chlorides and bromides were isolated without extraction and “filtered” over a short pad of silica gel; the use of solvents was greatly reduced in comparison with traditional isolation and purification A “one-pot” protocol for the conversion of thiol into sulfonamide is also demonstrated. Scale-up experiments on the preparation of sulfonyl chloride and bromide are shown. A possible reaction pathway is discussed. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives was written by Liu, Fang;Huai, Ziyou;Xia, Guotai;Song, Liuping;Li, Sha;Xu, Yulan;Hong, Kangjun;Yao, Mingyue;Liu, Gang;Huang, Yinjiu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Category: chlorides-buliding-blocks This article mentions the following:

A series of 6,7,8-trimethoxy-N-aryl-substituted-4-aminoquinazoline derivatives, e.g., I, were synthesized as epidermal growth factor receptor (EGFR) inhibitors, and their antitumor activities were assessed in the gastric cancer cell line SGC7901 using MTT assay. All compounds were found to inhibit SGC7901 cell proliferation, and compound I (IC₅₀ = 0.434 μM) was found to be slightly more effective against SGC7901 cells than epirubicin (IC₅₀ = 5.16 μM). This suggests that compound I can be used as a new substitution structure to develop more efficacious antitumor agents. Western blot anal. showed that treatment with I (40 μM for 30 min) resulted in near complete inhibition of EGF-induced ERK1/2 phosphorylation, indicating that its anti-proliferative effect is largely associated with inhibition of ERK1/2 activation. These data imply that I is a potential anticancer agent capable of inhibiting cell proliferation. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5Category: chlorides-buliding-blocks).

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of the precursors of iminosugars with 7-membered ring was written by Osuch-Kwiatkowska, Anna;Jarosz, Slawomir. And the article was included in Carbohydrate Research in 2022.Safety of (Chloromethanetriyl)tribenzene This article mentions the following:

D-Glucose was converted into the orthogonally protected open-chain derivative having different blocks at both terminal positions: C1 and C6. Selective deprotection of the C1-position opened a route to intermediate with the D-gluco-configuration, while deprotection at the C6-position gave the L-gulo isomer. In both derivatives, the oxime functionality was installed at the proper terminal position, which produced the corresponding precursors of a family of 7-membered ring iminosugars. One of these oximes was converted into the direct precursor 6,1-bromonitrile I. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Safety of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrophilic fluorination of N,N-dimethylaniline, N,N-dimethylnaphthalen-1-amine and 1,8-bis(dimethylamino)naphthalene with N-F reagents was written by Sorokin, Vladimir I.;Pozharskii, Alexander F.;Ozeryanskii, Valery A.. And the article was included in Journal of Fluorine Chemistry in 2013.Safety of 2-Chloro-N,N-dimethylaniline This article mentions the following:

Reaction of N,N-dimethylaniline, N,N-dimethylnaphthalen-1-amine and 1,8-bis(dimethylamino)naphthalene (proton sponge) with 1-chloromethyl-4-fluorodiazonia-bicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor) and N-fluorobenzenesulfonimide (NFSI) has been studied under various conditions. Unlike the proton sponge, which is fluorinated rather selectively at the ortho-position to NMe₂ group, producing 2-fluoro derivatives in moderate yield, two other amines react with Selectfluor and NFSI with strong tarring and the formation of complex mixtures of the corresponding biaryls, biarylmethanes and N-demethylated products. 2-Fluoro and 4-fluoro derivatives are also formed in minor quantities with the former isomer being predominant. Using the NFSI-ZrCl₄ system results in competitive chlorination of the aromatic ring. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Safety of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ultra-thin microporous membranes based on macrocyclic pillar[n]arene for efficient organic solvent nanofiltration was written by Fu, Wenming;Huang, Yangzheng;Deng, Luyao;Sun, Jiahao;Li, Shao-Lu;Hu, Yunxia. And the article was included in Journal of Membrane Science in 2022.Application of 4422-95-1 This article mentions the following:

Organic solvent nanofiltration (OSN) is a green, environmentally friendly and sustainable separation technol. High-performance OSN membranes are expected to play a critical role in the field of chem. separation involving organic solvents. However, traditional OSN membranes suffer from the constraints on perm-selectivity. Herein, we introduced macrocyclic mols. with intrinsic angstrom-size cavity, pillar[n]arene (P[n]a, n = 5, 6), as a novel aqueous monomer to react with trimesoyl chloride (TMC) to prepare highly perm-selective thin-film composite (TFC) OSN membranes through interfacial polymerization The prepared TFC-P[n]a membranes exhibit ultra-thin selective layer thickness of sub-10 nm and possess permanent intrinsic microporous structure, which endows the membrane with high perm-selectivity. Especially, the TFC-P[6]a membrane exhibits a high methanol permeance (8.10 L m^-2 h^-1 bar^-1) and a low mol. weight cut-off (MWCO) of 300 g mol^-1. In addition, the prepared TFC-P[n]a membranes exhibit mol. sieving function and could discriminate mols. with similar mol. weights but different shapes. Our work provides an insight of material design for the preparation of next-generation high-performance organic solvent nanofiltration membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Integration of a miniaturized DMMB assay with high-throughput screening for identifying regulators of proteoglycan metabolism was written by Sun, Yi;Tsui, Yuen-kee;Yu, Mengqi;Lyu, Minmin;Cheung, Kenneth;Kao, Richard;Leung, Victor. And the article was included in Scientific Reports in 2022.Reference of 61-73-4 This article mentions the following:

Defective biosynthesis or function of proteoglycans causes pathol. conditions in a variety of tissue systems. Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by progressive cartilage destruction caused by imbalanced proteoglycan synthesis and degradation Identifying agents that regulate proteoglycan metabolism may benefit the development of OA-modifying therapeutics. High-throughput screening (HTS) of chem. libraries has paved the way for achieving this goal. However, the implementation and adaptation of HTS assays based on proteoglycan measurement remain underexploited. Using primary porcine chondrocytes as a model, we report a miniaturized dimethyl-methylene blue (DMMB) assay, which is commonly used to quant. evaluate sulfated glycosaminoglycan (GAG) content, with an optimized detection range and reproducibility and its integration with HTS. Treatment with TGF-β1 and IL1-α, known as pos. and neg. proteoglycan regulators, resp., supported the assay specificity. A pre-test of chem. screening of 960 compounds identified both stimulators (4.48%) and inhibitors (6.04%) of GAG production Fluorophore-assisted carbohydrate electrophoresis validated the activity of selected hits on chondroitin sulfate expression in an alginate culture system. Our findings support the implementation of this simple colorimetric assay in HTS to discover modifiers of OA or other diseases related to dysregulated proteoglycan metabolism In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Reference of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scandium triflate-catalyzed transesterification of carboxylic esters was written by Remme, Nicole;Koschek, Katharina;Schneider, Christoph. And the article was included in Synlett in 2007.Safety of Methyl 2-chloro-2-phenylacetate This article mentions the following:

The direct transesterification of carboxylic esters is efficiently catalyzed with Sc(OTf)₃ (10 mol%) in boiling alc. solvent. Me, Et, iso-Pr, and allyl esters were prepared from a broad range of different substrates in high yields. The application of microwave irradiation led to significantly reduced reaction times. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Safety of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis was written by Obermayer, David;Znidar, Desiree;Glotz, Gabriel;Stadler, Alexander;Dallinger, Doris;Kappe, C. Oliver. And the article was included in Journal of Organic Chemistry in 2016.SDS of cas: 3438-16-2 This article mentions the following:

A newly designed robust and safe laboratory scale reactor for syntheses under sealed-vessel conditions at 250° maximum temperature and 20 bar maximum pressure is presented. The reactor uses conductive heating of a sealed glass vessel via a stainless steel heating jacket and implements both online temperature and pressure monitoring in addition to magnetic stirring. Reactions are performed in 10 mL borosilicate vials that are sealed with a silicone cap and Teflon septum and allow syntheses to be performed on a 2-6 mL scale. This conductively heated reactor is compared to a standard single-mode sealed-vessel microwave instrument with respect to heating and cooling performance, stirring efficiency, and temperature and pressure control. Importantly, comparison of the reaction outcome for a number of different synthetic transformations performed side by side in the new device and a standard microwave reactor suggest that results obtained using microwave conditions can be readily mimicked in the operationally much simpler and smaller conventionally heated device. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2SDS of cas: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics