Month: February 2023

Reactivity of benzylic acylammonium chlorides. A novel method for the synthesis of N-phenacylamides was written by Coskun, Necdet;Tirli, Fatma. And the article was included in Synthetic Communications in 1997.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Tertiary amines R¹C₆H₄CH₂NR²CH₂COC₆H₄R³-4 [R¹ = H, 2,3-(MeO)₂, 3,4-(MeO)₂, 2-NO₂, etc., R² = Me, PhCH₂, 3,4-(MeO)₂C₆H₃CH₂, R³ = H, MeO] reacted with acid chlorides R⁴COCl [R⁴ = 3-MeOC₆H₄CH₂, 3,4-(MeO)₂C₆H₄CH₂, PhCH₂, 4-MeOC₆H₄CH₂] to give corresponding benzyl chlorides and N-phenacylamides R⁴CONR²CH₂COC₆H₄R³-4. The effect of the substituents in the benzyl group on the reactivity of the intermediate acylammonium chlorides was investigated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and identification of novel berberine derivatives as potent inhibitors against TNF-α-induced NF-κB activation was written by Wang, Yan-Xiang;Liu, Lu;Zeng, Qing-Xuan;Fan, Tian-Yun;Jiang, Jian-Dong;Deng, Hong-Bin;Song, Dan-Qing. And the article was included in Molecules in 2017.Related Products of 777-44-6 This article mentions the following:

Twenty-three new berberine (BBR) analogs containing substituents on ring D, I [R¹ = OMe, NH₂, cyclopropanecarbonyloxy, (4-nitrophenyl)sulfonyloxy, etc., R² = OMe, (adamantan-1-yl)acetoxy, (adamantane-10-carbonyloxy)], were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure-activity relationship (SAR) anal. indicated that suitable tertiary/quaternary carbon substitutions at the 9-position or a rigid fragment at position 10 might be beneficial for enhancing their anti-inflammatory potency. Among them, compounds I [R¹ = (1-methylcyclohexane-1-carbonyl)oxy, 2-(bicyclo[2.2.1]heptan-2-yl)acetoxy, (2′-propylpentanoyl)oxy, (p-tert-butylbenzoyl)oxy, R² = OMe] exhibited satisfactory inhibitory potency against NF-κB activation, with an inhibitory rate of around 90% (5 μM), much better than BBR. A preliminary mechanism study revealed that all of them could inhibit TNF-α-induced NF-κB activation via impairing IκB kinase (IKK) phosphorylation as well as cytokines interleukin (IL)-6 and IL-8 induced by TNF-α. Therefore, the results provided powerful information on further structural modifications and development of BBR derivatives into a new class of anti-inflammatory candidates for the treatment of inflammatory diseases. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, cytotoxic activities and molecular modeling studies of some 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives was written by Yanik, Hulya;Ayan, Sumeyra;Akdemir, Atilla;Erdogan, Omer;Ustundag, Cem Bulent;Cevik;Yilmaz, Ozge Ozgur. And the article was included in Organic Communications in 2020.Computed Properties of C7H3Cl2NS This article mentions the following:

A series of 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives I (R = 4-methylphenyl, 2,4-dichlorophenyl, cyclohexyl, etc.) was synthesized and their structures were verified with spectral anal. In vitro cytotoxic activities of the synthesized compounds I were evaluated by using MTT assay against MKN-45 (Human Gastric cancer), MDA-MB-231 (Human Breast cancer) and HeLa (Human Cervical cancer) cell lines. Among the synthesized compounds, I (R = 4-trifluoromethylphenyl) inhibited MDA-MB-cell proliferation with an IC₅₀ value of 0.276μM. Compound I (R = 4-fluorophenyl) inhibited HeLa and MKN-45 cell proliferation with IC₅₀ values of 0.336μM and 8.769μM, resp. Compound I (R = 4-methoxyphenyl) inhibited HELA cell proliferation with an IC₅₀ value of 0.269μM. Mol. docking results suggest that the ligands may bind to the hDNA TopoIIβ binding pocket and partially exert their effects. These results propose that 2-aminonaphtho[2,3-d]thiazole-4,9-dion core has important biol. effects and further explorations are worthwhile. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxidation of triethylene glycol by N-chlorosaccharin in cetyltrimethylammonium bromide catalyzed system: a kinetics and mechanistic study was written by Sharma, Vandana;Sharma, K. V.;Bhagwat, V. W.. And the article was included in Physical Chemistry: An Indian Journal in 2008.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The kinetics and mechanistic study of cetyltrimethylammonium bromide catalyzed oxidation of triethylene glycol [2,2′-ethylene dioxybis(ethanol)] by N-chlorosaccharin in aqueous acetic acid medium in presence of perchloric acid were studied at 303-323K temperature range. The reaction has first order dependence on N-chlorosaccharin concentration The reaction rate follows first order kinetics with respect to [triethylene glycol] with excess concentration of other reactants. The micelle effect due to cetyltrimethylammonium bromide- a cationic surfactant was studied. The change in ionic strength shows negligible salt effect. The dielec. effect is pos. Addition of one of (saccharin) retards the reaction rate. Activation parameters are calculated from the Arrhenius plot. A suitable mechanism was proposed in consistence with the kinetic data. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-catalyzed decarboxylative arylation of azoles with perfluoro- and nitrobenzoates was written by Crawford, Jennifer M.;Shelton, Kyle E.;Reeves, Emily K.;Sadarananda, Bryce K.;Kalyani, Dipannita. And the article was included in Organic Chemistry Frontiers in 2015.Recommanded Product: 225104-76-7 This article mentions the following:

This manuscript describes a Ni-catalyzed method for the direct arylation of azoles using benzoates. Perfluorophenyl and 2-nitrobenzoates participate in these reactions to afford the corresponding products, e.g., I, in modest to good yields. The efficiency of the arylations with perfluorobenzoates is highly dependent on both the degree and position of fluorine atoms in the benzoates. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7Recommanded Product: 225104-76-7).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 225104-76-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Combinatorial Approach to N-Substituted Amino-Cyclitol Libraries by Solution-Phase Parallel Synthesis and Preliminary Evaluation as Glucocerebrosidase Inhibitors was written by Serrano, Pedro;Casas, Josefina;Zucco, Martine;Emeric, Gilbert;Egido-Gabas, Meritxell;Llebaria, Amadeu;Delgado, Antonio. And the article was included in Journal of Combinatorial Chemistry in 2007.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Libraries of N-substituted amino-cyclitol derivatives of the scyllo and racemic chiro series by means of parallel solution-phase methodol. with the help of robotic technol. are described. Chem. diversity has been introduced by reaction of selected scaffolds with a set of aldehydes, acyl chlorides, sulfonyl chlorides, chloroformates, and amines to afford the corresponding amines, amides, sulfonamides, carbamates and ureas, resp. The optimized methodol. has proven excellent, in terms of overall purity of the resulting libraries, for the production of amides. Sulfonamides and carbamates have been obtained in slightly lower purity, while amines afforded modest results. Selected library members have been evaluated as inhibitors of recombinant glucocerebrosidase with K_i values ranging in the low micromolar scale for the most active members. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents was written by Blindheim, Fredrik Heen;Olsen, Cecilie Elisabeth;Krogh Soegaard, Caroline;Otterlei, Marit;Sundby, Eirik;Hoff, Baard Helge. And the article was included in European Journal of Organic Chemistry in 2021.Quality Control of (Chloromethanetriyl)tribenzene This article mentions the following:

Imidazopyridinones I (R = H, OMe) and 7-azaoxindole II are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chem. Various synthetic methods and routes have been evaluated to identify safe and robust chem. to advanced imidazopyridinone I building blocks and inhibitor structures. Preparation of the 7-azaoxindoles II was challenged by instability of the core scaffold. Key to the successful isolation of the target structure was development of a mild Suzuki cross-coupling in non-aqueous media. The imidazopyridinones I were potent inhibitors of the E. coli thymidylate monophosphate kinase, while the 7-azaoxindole II showed low activity. The compounds were inactive in cell-based studies, indicating poor cell wall penetration. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Quality Control of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure and absolute configuration of some 5-chloro-2-methoxy-N-phenylbenzamide derivatives was written by Galal, Alaaeldin M. F.;Shalaby, Elsayed M.;Abouelsayed, Ahmed;Ibrahim, Medhat A.;Al-Ashkar, Emad;Hanna, Atef G.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2018.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The absolute configuration of 5-chloro-2-methoxy-N-phenylbenzamide single crystal [compound (1)] and the effect of introducing -[CH₂]_n-, n = 1,2 group adjacent to the amide group [compounds (2) and (3)], were studied. Furthermore, the replacement of the methoxy group with a hydroxy group [compound (4)] was defined. Proton and carbon-13 NMR spectrometer were used to record the structural information of the prepared compounds X-ray single crystal diffractometer were used to elucidate the 3D structural configurations. Intensity data for the studied compounds were collected at room temperature The X-ray data prove that compound (1) is almost planar, with maximum r.m.s. deviations of 0.210(3) Å corresponds to C13. This planarity starts to disturb by adding -[CH₂]_n-, n = 1,2 groups between the NH group and the Ph ring in compounds (2) and (3), resp. By replacing the OCH₃ group by an OH group in compound (4), the plane of the chlorophenyl moiety is nearly perpendicular to that of the Ph ring. Such new structural configurations were further illustrated by the IR, and UV-visible spectroscopy measurements in the frequency range 400-4000 cm ^-1 and 190-1100 nm, resp. Spectroscopic analyses were verified with the help of mol. modeling using d. functional theory. The estimated total dipole moment for the prepared compounds reflects its ability to interact with its surrounding mols. The higher dipole moment for a given structures is combined with the higher reactivity for potential use in medicinal applications. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation was written by Kaur, Gaganpreet;Silakari, Om. And the article was included in Bioorganic Chemistry in 2018.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Designing of hybrid drugs with specific multitarget profile is a promising line of attack against inflammation. In light of this, a series of benzimidazole scaffold based hybrid mols. were designed by integrating benzimidazoles (containing pharmacophoric elements for COXs and LOXs inhibitors) with phthalimide subunit of thalidomide (pharmacophore element for TNF-α inhibitor) under one construct via mol. hybridization strategy. The designed mols. were synthesized and evaluated for their inhibitory activity against COXs (COX-1, COX-2), LOXs (5-LOX, 15-LOX) enzymes as well as TNF-α inhibitory effect. The results revealed that, compounds (3a-l) obtained showed inhibition in submicromolar range against COXs and LOXs targets whereas milder inhibitory activity was obtained against lipopolysaccharides (LPS)-induced TNF-α secretion by murine macrophage-like cells (RAW264.7). Within this class of compounds, I emerged as having alluring multiple inhibitory effects on set of COX-1/2 and 5-/15-LOX enzymes (COX-1 IC₅₀ = 9.85 μM; COX-2 IC₅₀ = 1.00 μM; SI = 9.85; 5-LOX IC₅₀ = 0.32 μM; 15-LOX IC₅₀ = 1.02 μM) in conjunction with a good anti-inflammatory and analgesic activities. Addnl., compound I showed gastrointestinal safety with reduced lipid peroxidation Docking results of compound I with COX-2 and 5-LOX were also consistent with the in vivo anti-inflammatory results. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New protecting groups for the indole ring of tryptophan in peptide synthesis: 2,4,6-trimethoxybenzenesulfonyl and 4-methoxy-2,3,6-trimethylbenzenesulfonyl groups was written by Fukuda, Tsunehiko;Wakimasu, Mitsuhiro;Kobayashi, Shigeru;Fujino, Masahiko. And the article was included in Chemical & Pharmaceutical Bulletin in 1982.Application of 63624-28-2 This article mentions the following:

The title groups (Mtb and Mtr, resp.) and 2,4-RR¹C₆H₃SO₂ (R = H, R¹ = Me, MeO; R = R¹ = MeO) were introduced at the Nⁱⁿ of tryptophan, and their protective group properties were studied. Thus, Boc-Trp-OCH₂Ph (Boc = Me₃CO₂C) was treated with R²Cl (R² = Mtb, Mtr) to give Boc-Trp(R²)-OCH₂Ph, which was saponified to give Boc-Trp(R²)-OH. Mtb and Mtr were stable to CF₃CO₂H, but they can be removed by HF or MeSO₃H; these groups suppress decomposition and modification of the tryptophan residue during peptide synthesis. The Mtb and Mtr groups were used for the protection of the indole ring in the synthesis of pyro-Glu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ (bombesin) and LH-releasing hormone analog pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt by solution methods and the preparation of H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH (dynorphin) by the solid-phase method. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics