Month: February 2023

Iodide-Catalyzed Carbonylation-Benzylation of Benzyl Chlorides with Potassium Aryltrifluoroborates under Ambient Pressure of Carbon Monoxide was written by Han, Wei;Chen, Junjie;Jin, Fengli;Yuan, Xiaorong. And the article was included in Synlett in 2018.Electric Literature of C8H9Cl This article mentions the following:

The novel transition-metal free synthesis of a wide range of 1,2,3-triarylpropan-1-ones R¹CH₂CHR¹C(O)R² (R¹ = Ph, 3,4-Cl₂C₆H₃, 3-MeOC₆H₄, etc.; R² = Ph, 4-FC₆H₄, 2-naphthyl, etc.) in high yields was developed via tetrabutylammonium iodide-catalyzed carbonylation-benzylation of unactivated benzyl chlorides R¹CH₂Cl with potassium aryltrifluoroborates R²BF₃K using CO gas under ambient pressure. This protocol provides an inexpensive and operationally simple method for synthesis of 1,2,3-triarylpropan-1-ones and represented a significant improvement over the traditional palladium-catalyzed carbonylation. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Electric Literature of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The pH sensitive fluorescence SiO₂@TEuTTA/CS composite films and inks for anti-counterfeiting was written by Li, Le;Xi, Peng;Li, Quan;Wang, Xiaoqing;Cheng, Bowen. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

Functional chitosan (CS) composite films have wide application prospects in many fields. Herein, the lanthanide inorganic-organic hybrid nanospheres with an average diameter of 252 nm (SiO₂@TEuTTA) were synthesized by surface modification of silica nanospheres. And the SiO₂@TEuTTA was used as luminescent materials and SiO₂@TEuTTA/CS composite films were prepared by a simple solution casting method. Subsequently, the compositions and structure, fluorescence and mech. properties of the SiO₂@TEuTTA/CS composite films were characterized. The results show that the SiO₂@TEuTTA/CS composite films not only have the smooth surface, high fluorescence property, good flexibility and transparency, but also can emit a bright red color under a 365 nm UV lamp. These provide an important basis for the application of the SiO₂@TEuTTA/CS composite films on the anti-counterfeiting packing labels. Addnl., the SiO₂@TEuTTA/CS solutions have been successfully used as anti-counterfeiting inks due to its transparency and pH sensitive properties. Compared with the traditional luminescent anti-counterfeiting inks, the pH sensitive SiO₂@TEuTTA/CS inks can improve the level of information security, which indicates that the SiO₂@TEuTTA/CS inks hold great promise for anti-counterfeiting fields. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and bioactivities of phenazine-1-carboxylic piperazine derivatives was written by Han, Fei;Yan, Ru;Zhang, Min;Xiang, Zhu;Wu, Qinglai;Li, Junkai. And the article was included in Natural Product Research in 2020.Application of 620-19-9 This article mentions the following:

Phenazine-1-carboxylic acid (PCA) as a natural product which has significant inhibition effects against many soil-borne fungal phytopathogens in agricultural application and has been registered in China as the fungicide against rice sheath blight. In order to find new higher fungicidal activities lead compounds and develop new eco-friendly agrochems., we introduced substructure piperazines which also have high biol. activity into PCA, designed and synthesized a series of phenazine-1-carboxylic piperazine derivatives, and their structures were confirmed by ¹H NMR and HRMS. Most compounds exhibited certain in vitro fungicidal activities. In particular, Compounds exhibited the activity against all the tested pathogenic fungi, such as Rhizoctonia solani, Alternaria solani, Fusarium oxysporum, Fusarium graminearum, Pyricularia oryzae Cavgra, with the EC₅₀ value of 24.6渭M, 42.9渭M, 73.7渭M, 73.8渭M, 34.2渭M, resp., more potent activities than PCA (33.2渭M, 81.5渭M, 186.5渭M, 176.4渭M, 37.3渭M). This result provided a highly active lead compound for the further structure optimization design. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-doped carbon intercalated Fe-doped MoS₂ nanosheets with widened interlayer spacing: An efficient peroxymonosulfate activator for high-salinity organic wastewater treatment was written by Chen, Xi;Li, Songrong;Yang, Peizhen;Chen, Yunfeng;Xue, Cheng;Long, Yuhan;Han, Jiayan;Su, Jianming;Huang, Wenli;Liu, Dongfang. And the article was included in Journal of Colloid and Interface Science in 2022.Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

Peroxymonosulfate (PMS) heterogeneous catalysis dominated by nonradical pathway showed excellent adaptability for pollutant removal in complex water matrixes. Herein, ultra-small Fe-doped MoS₂ nanosheets with N-doped carbon intercalation (CF-MoS₂) were synthesized via a one-step hydrothermal method to treat high salinity organic wastewater. CF-MoS₂ exhibited an expanded interlayer spacing by 1.63 times and the sp. surface area by 9 times compared with Fe-doped MoS₂ (F-MoS₂), substantially increasing the active sites. Homogeneous Fe2+ catalytic experiments confirmed that the promotion of carbon intercalated MoS₂ (C-MoS₂) on Fe³⁺/Fe²⁺ redox cycle was much higher than pure MoS₂. Besides, the considerable removal of tetracycline (TC) under high salinity conditions (0-7.1%) was attributed to the dominant role of PMS nonradical oxidation pathways, including ¹O₂ and surface-bound radicals. The catalytic sites included Fe³⁺/Fe²⁺, Mo⁴⁺/Mo⁵⁺/Mo⁶⁺, C=O, pyridine N, pyrrolic N and hydroxyl groups. Finally, d. functional theory (DFT) was employed to get the radical electrophilic attack sites and nucleophile attack sites of TC, and the results were consistent with the TC degradation products determined by HPLC-MS. This work would broaden the application of MoS₂-based catalysts, especially for PMS catalytic removal of organic pollutants from high salinity wastewater. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An approach to 1-alkyl-3-phenylpiperidine derivatives containing 2,5-functionalized groups: 1-methyl-2-(4-chlorophenylthiomethyl)-3-(3-methoxyphenyl)-5-(methoxycarbonyl)piperidine was written by Kotzamani, Heleni K.;Gourdoupis, Christos G.;Stamos, Ioannis K.. And the article was included in Tetrahedron in 1994.Reference of 6834-42-0 This article mentions the following:

3-MeOC₆H₄CH₂COCH₂SC₆H₄Cl-4 (I) was synthesized by regiospecific addition of 4-chlorothiophenol to diazoketone 3-MeOC₆H₄CH₂COCHN₂ in the presence of a rhodium(II) acetate catalyst. Annulation of I with the enamine prepared from MeNH₂ and CH₂:C(CH₂Br)CO₂Me gave a tetrahydropyridine derivative Reduction of this compound with sodium cyanoborohydride in the presence of carboxylic acid produced the title compound In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper oxide nanoparticles using Mentha spicata leaves as antibacterial, antibiofilm, free radical scavenging agent and efficient photocatalyst to degrade methylene blue dyes was written by Malaikozhundan, Balasubramanian;Lakshmi, Venkatesan Namagiri;Krishnamoorthi, Raman. And the article was included in Materials Today Communications in 2022.Recommanded Product: 61-73-4 This article mentions the following:

In this findings, CuO NPs were made by an easy, eco-friendly, and economical approach using the leaf extract of M. spicata. The prepared Ms-CuO NPs exhibited characteristic absorbance peak at 320 nm with a band gap of 3.87 eV. XRD revealed the presence of crystalline particle with size of 11.28 nm as determined by the Scherrer equation. FTIR revealed the role of various functional mols. in the bio-reduction of copper salts to copper ions (Cu²⁺). The spherical shaped particles with the mean size of 36 nm were visualized through TEM microscopic image. EDX anal. also confirmed the elemental signals of Cu (91.58%) and O (8.42%) resp. The biosynthesized Ms-CuO NPs displayed a significant inhibition of Gram-pos. Streptococcus pyogenes and Staphylococcus aureus at all tested concentrations The inhibition size against S. pyogenes and S. aureus was 27.5 卤 0.5 mm and 26.2 卤 0.2 mm at 100渭g mL^-1 resp. On the other hand, the inhibition against K. pneumoniae and E. coli was 17.4 卤 0.6 mm and 18.2 卤 0.1 mm at 100渭g mL^-1 resp. Moreover, a significant inhibition of H₂O₂ (84%) at 100渭g mL^-1 demonstrates the free radical scavenging activity of Ms-CuO NPs. Furthermore, the Ms-CuO NPs have shown excellent degradation potential for industrial dyes i.e., Methylene blue (MB) and was noticed by the gradual decrease in the absorbance (at 460 nm) within 7 h of reaction. The percentage of MB dye degraded was 34% at 1 h which was substantially increased to 98% after 7 h. This study suggests that the Ms-CuO NPs may serve as a promising bactericidal, antibiofilm and antioxidant agent. Also, Ms-CuO NPs could be effectively used in the purification of water bodies contaminated with harmful industrial dyes to reduce toxicity. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of novel icariin derivatives was written by Wang, A.;Zhang, Aili;Xu, Y.. And the article was included in Pharmazie in 2019.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A series of aromatic sulfonyls substituted icariin derivatives I (R = 4-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, etc.) was synthesized and their antibacterial activities against S. aureus (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound I (R = 4-F₃CC₆H₄) exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S. aureus (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and mol. docking anal. indicated that compound I (R = 4-F₃CC₆H₄) might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant S. aureus. Surface plasmon resonance (SPR) experiment further confirmed the binding affinity. Therefore, aromatic sulfonyls at C-3 position substituted icariin derivatives have been considered to be a novel class of anti-MRSA agents worth of further investigation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents was written by Kong, Xiangkai;Yao, Zeyu;He, Zuopeng;Xu, Wenfang;Yao, Jianwen. And the article was included in MedChemComm in 2015.HPLC of Formula: 6590-96-1 This article mentions the following:

A series of thiourea and nicotinamide-containing sorafenib analogs (7a-n) were designed and synthesized and their antiproliferative activities were tested against HCT116, MDA-MB-231, PC-3 and HepG2 cell lines. Most of the compounds showed potent activities against the four cell lines, compound 7h showed better activities than sorafenib against all four cell lines, and compounds 7a and 7e showed better activities against HCT116 and MDA-MB-231 cell lines. The anti-angiogenic activities of 7e and 7h were also better than that of sorafenib in both in vitro HUVEC tube formation assay and ex vivo rat thoracic aorta ring assay. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solid-phase synthesis of 2,3-diphenylpropionic acid library as VLA-4 antagonists was written by Hoshina, Yoichiro;Ikegami, Satoru;Fujimoto, Kyoko;Okuyama, Akihiko;Harada, Tatsuhiro;James, Susan;Griffiths, Peter G.;Wu, Zemin;Lilly, Michael;Bray, Andrew M.. And the article was included in Tetrahedron Letters in 2005.Recommanded Product: 3-Cyanobenzoyl chloride This article mentions the following:

A 2,3-diphenylpropionic acid library was synthesized on solid-phase. There are two practical synthetic routes via an orthogonal generation of two aromatic amino functional groups. Several compounds were identified as potent VLA-4 antagonists. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Recommanded Product: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics