Month: February 2023

1-(2-Thienyl)-2-phenylethylamines as potential non-stimulant anorectics was written by Mrongovius, R. I.;Ghosh, P.;Bolt, A. G.;Ternai, B.. And the article was included in Arzneimittel-Forschung in 1981.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Thirty-one 1-(2-thienyl)-2-phenylethylamines I (R = H, Cl, F, Br, CF₃, Me, OMe, or NO₂; R¹ = H or Et; and R² = H, Et, Ac, iso-Pr, or benzyl) were prepared and tested for anorectic and motor-stimulating activity. About half of the compounds produced anorexia and only one of these active agents increased motor activity. The 3 most potent anorectics without motor-stimulating activity were 1-(2-thienyl)-2-(4-chlorophenyl)ethylamine-HCl聽聽[80154-70-7], N-isopropyl-1-(2-thienyl)-2-(4-chlorophenyl)ethylamine-HCl聽聽[80154-71-8], and N-isopropyl-1-(2-thienyl)-2-(4-fluorophenyl)ethylamine-HCl聽聽[80154-82-1]. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reprint of “CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals” was written by Verstraelen, Sandra;Maglennon, Gareth;Hollanders, Karen;Boonen, Francis;Adriaens, Els;Alepee, Nathalie;Drzewiecka, Agnieszka;Gruszka, Katarzyna;Kandarova, Helena;Willoughby, Jamin A. Sr.;Guest, Robert;Schofield, Jane;Van Rompay, An R.. And the article was included in Toxicology In Vitro in 2018.COA of Formula: C10H8Cl2FNO3 This article mentions the following:

Assessment of ocular irritation potential is an international regulatory requirement in the safety evaluation of industrial and consumer products. None in vitro ocular irritation assays are capable of fully categorizing chems. as stand-alone. Therefore, the CEFIC-LRI-AIMT6-VITO CON4EI consortium assessed the reliability of eight in vitro test methods and computational models as well as established a tiered-testing strategy. One of the selected assays was Bovine Corneal Opacity and Permeability (BCOP). In this project, the same corneas were used for measurement of opacity using the OP-KIT, the Laser Light-Based Opacitometer (LLBO) and for histopathol. anal. The results show that the accuracy of the BCOP OP-KIT in identifying Cat 1 chems. was 73.8% while the accuracy was 86.3% for No Cat chems. BCOP OP-KIT false neg. were often related to an in vivo classification driven by conjunctival effects only. For the BCOP LLBO, the accuracy in identifying Cat 1 chems. was 74.4% vs. 88.8% for No Cat chems. The BCOP LLBO seems very promising for the identification of No Cat liquids but less so for the identification of solids. Histopathol. as an addnl. endpoint to the BCOP test method does not reduce the false neg. rate substantially for in vivo Cat 1 chems. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6COA of Formula: C10H8Cl2FNO3).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C10H8Cl2FNO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic pyrolysis of Alcea pallida stems in a fixed-bed reactor for production of liquid bio-fuels was written by Aysu, Tevfik. And the article was included in Bioresource Technology in 2015.HPLC of Formula: 3386-33-2 This article mentions the following:

Pyrolysis of Alcea pallida stems was performed in a fixed-bed tubular reactor with and without catalyst at three different temperatures The effects of pyrolysis parameters including temperature and catalyst on the product yields were investigated. It was found that higher temperature resulted in lower liquid (bio-oil) and solid (bio-char) yields and higher gas yields. Catalysts had different effects on product yields and composition of bio-oils. Liquid yields were increased in the presence of zinc chloride and alumina but decreased with calcium hydroxide, tincal and ulexite. The highest bio-oil yield (39.35%) by weight including aqueous phase was produced with alumina catalyst at 500 掳C. The yields of bio-char, bio-oil and gas produced, as well as the compositions of the resulting bio-oils were determined by elemental anal., TGA, FT-IR and GC-MS. 160 different compounds were identified by GC-MS in the bio-oils obtained at 500 掳C. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2HPLC of Formula: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions was written by Magnus, Christopher J.;Lee, Peter H.;Atasoy, Deniz;Su, Helen H.;Looger, Loren L.;Sternson, Scott M.. And the article was included in Science (Washington, DC, United States) in 2011.Category: chlorides-buliding-blocks This article mentions the following:

Ionic flux mediates essential physiol. and behavioral functions in defined cell populations. Cell type-specific activators of diverse ionic conductances are needed for probing these effects. We combined chem. and protein engineering to enable the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharmacol. selectivity and divergent functional properties. The LGICs and their small-mol. effectors were able to activate a range of ionic conductances in genetically specified cell types. LGICs constructed for neuronal perturbation could be used to selectively manipulate neuron activity in mammalian brains in vivo. The diversity of ion channel tools accessible from this approach will be useful for examining the relationship between neuronal activity and animal behavior, as well as for cell biol. and physiol. applications requiring chem. control of ion conductance. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Category: chlorides-buliding-blocks).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core was written by Fotsch, Christopher;Biddlecome, Gloria;Biswas, Kaustav;Chen, Jian Jeff;D’Amico, Derin C.;Groneberg, Robert D.;Han, Nianhe Bruce;Hsieh, Feng-Yin;Kamassah, Augustus;Kumar, Gondi;Lester-Zeiner, Dianna;Liu, Qingyian;Mareska, David A.;Riahi, Babak Bobby;Wang, Yueh-Ju Judy;Yang, Kevin;Zhan, James;Zhu, Joe;Johnson, Eileen;Ng, Gordon;Askew, Benny C.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Related Products of 1138-56-3 This article mentions the following:

The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC₅₀s < 20 nM in a B1 receptor functional assay. One of these compounds, I, shows modest oral bioavailability in rats. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Related Products of 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Structure, and Reactivity of Iridium(III) Complexes Containing a 4,6-Dimethyl-1,3-benzenediphenylimine Pincer Ligand was written by Wingard, Leah A.;Finniss, Mathew C.;Norris, Michael;White, Peter S.;Brookhart, Maurice;Templeton, Joseph L.. And the article was included in Inorganic Chemistry in 2013.Recommanded Product: Chlorobis(ethylene)iridium(I) dimer This article mentions the following:

A nonheterocyclic bis(imino)aryl ligand with blocking Me substituents, 4,6-dimethyl-1,3-benzenediphenylimine (NCHN), has been synthesized. Metalation via oxidative addition proceeds under mild conditions with the Ir(I) reagent [Ir(CH₂=CH₂)₂(Cl)]₂ to produce the Ir(III) product (NCN)Ir(CH₂CH₃)(Cl). Neutral nucleophiles such as water or triphenylphosphine add readily to the vacant sixth coordination site. Protonation of the Et group results in loss of ethane and formation of a dicationic chloride-bridged (NCN)Ir dimer. Alternatively, the chloride ligand can be abstracted from (NCN)Ir(CH₂CH₃)(Cl) to provide access to various neutral and cationic species, including (NCN)Ir(CH₂CH₃)(OAc) (OAc = acetate), [(NCN)Ir(CH₂CH₃)(bpy)][BF₄] (bpy = 4,4′-bipyridine), [(NCN)Ir(CH₂CH₃)(NCCH₃)₂][BF₄], and [(NCN)Ir(CH₂CH₃)(OH₂)₂][BF₄], which is water soluble In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Recommanded Product: Chlorobis(ethylene)iridium(I) dimer).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: Chlorobis(ethylene)iridium(I) dimer

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ethyl 4-chloro-3-nitrobenzoate was written by Li, Hao-Yuan;Liu, Bo-Nian;Tang, Shi-Gui;Xu, Ye-Ming;Guo, Cheng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2008.Product Details of 16588-16-2 This article mentions the following:

In the mol. of Et 4-chloro-3-nitrobenzoate, C₉H₈ClNO₄, an intramol. C-H路路路O H bond gave a planar 5-membered ring, which is nearly coplanar with the adjacent 6-membered ring, the rings being oriented at a dihedral angle of 4.40(3)掳. In the crystal structure, intermol. C-H路路路O H bonds link the mols. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Product Details of 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural Re-engineering of the 伪-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates was written by Drennen, Brandon;Scheenstra, Jacob A.;Yap, Jeremy L.;Chen, Lijia;Lanning, Maryanna E.;Roth, Braden M.;Wilder, Paul T.;Fletcher, Steven. And the article was included in ChemMedChem in 2016.Synthetic Route of C8H8ClNO3 This article mentions the following:

The disruption of aberrant protein-protein interactions (PPIs) with synthetic agents remains a challenging goal in contemporary medicinal chem. but some progress has been made. One such dysregulated PPI is that between the anti-apoptotic Bcl-2 proteins, including myeloid cell leukemia-1 (Mcl-1), and the 伪-helical Bcl-2 homol.-3 (BH3) domains of its pro-apoptotic counterparts, such as Bak. Herein, we describe the discovery of small-mol. inhibitors of the Mcl-1 oncoprotein based on a novel chemotype. Particularly, re-engineering of our 伪-helix mimetic JY-1-106 into 2,6-di-substituted nicotinates afforded inhibitors of comparable potencies but with significantly decreased mol. weights The most potent inhibitor 2-(benzyloxy)-6-(4-chloro-3,5-dimethylphenoxy)nicotinic acid (1 r: K_i=2.90 渭m) likely binds in the p2 pocket of Mcl-1 and engages R263 in a salt bridge through its carboxylic acid, as supported by 2D ¹H-¹⁵N HSQC NMR data. Significantly, inhibitors were easily accessed in just four steps, which will facilitate future optimization efforts. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-2-methoxynicotinate (cas: 65515-32-4Synthetic Route of C8H8ClNO3).

Methyl 6-chloro-2-methoxynicotinate (cas: 65515-32-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H8ClNO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arenesulfonic acid derivatives. XI. Synthesis of sulfonamides, hydrazides, and ureas containing a benzofuran moiety was written by Kaldrikyan, M. A.;Geboyan, V. A.;Aroyan, A. A.;Stepanyan, N. O.;Sapondzyan, L. G.;Sarkisyan, L. M.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1980.Synthetic Route of C10H13ClO3S This article mentions the following:

Sixteen amides I (R, R¹ = Me, Et, Pr, Bu) were obtained in 61-91% yield by reaction of p-ROC₆H₄SO₂Cl (II) with the corresponding benzofuranylalkylamine. Treatment of 2-benzofurancarboxylic hydrazide with II gave 72-80% III, which could also be obtained using the benzofurancarbonyl chloride and p-ROC₆H₄SO₂NHNH₂. Eight IV (R = Me, Et, Pr, Bu; R¹ = Me, Et) were obtained in 45-74% yield by reaction of p-ROC₆H₄SO₂NHCO₂Et with the corresponding benzofuranylalkylamine. The hypoglycemic and anticonvulsive properties of I, III and IV were determined; none exhibited anticonvulsive properties and I (R = R¹ = Pr) reduced blood glucose content by 20% at 250 mg/kg. All the remaining compounds exhibited hyperglycemic activity. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Synthetic Route of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of biaryls via intramolecular free radical ipso-substitution reactions was written by Ujjainwalla, Feroze;da Mata, Maria Lucilia E. N.;Pennell, Andrew M. K.;Escolano, Carmen;Motherwell, William B.;Vazquez, Santiago. And the article was included in Tetrahedron in 2015.Application of 63624-28-2 This article mentions the following:

A variety of functionalized biaryls and heterobiaryls are prepared by intramol. free radical [1,5]-ipso-substitution using sulfonamide and sulfonate derived tethering chains. The overall efficiency of the process is determined by appropriately positioned substituents on the aromatic acceptor ring. The extension of the process to benzylic sulfonates and their corresponding N-methylsulfonamide alternatives as substrates in potential [1,6]-ipso-substitution reactions leads mainly to the alternative [1,7] addition products. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics