Month: February 2023

New information indexes for interactions in biological systems was written by Motoo, Ioan. And the article was included in MATCH in 1981.Application of 34662-36-7 This article mentions the following:

The superposition of n effectors in a given series reflects the topol. of the receptor space explored by the considered effectors. The investigated receptor space (IRS) is defined as the graph G whose overlap partition is G₁, …, G_n. The graph, G₁ (1 鈮?L 鈮?n), is the hydrogen-suppressed graph corresponding to the effector mol., L. One computes the mean [I虆(G)] and total [I(G)] quantity of information contained in the IRS. I(G) or I虆(G) induces an ordering of IRS’s and constitutes a criterion for IRS relevance. These indexes are of use in quant. structure-activity relations. Two concrete series of hapten-antibody interactions and one series of carboxypeptidase inhibitors were studied. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Application of 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity of functionalized arylcarbenes. 2-Phenylethyl side chains and hetero analogs was written by Kirmse, Wolfgang;Konrad, Wolfgang;Ozkir, Ismail S.. And the article was included in Tetrahedron in 1997.SDS of cas: 7476-66-6 This article mentions the following:

Phenylcarbenes with -X-CH₂Ph and -CH₂X-Ph (X = CH₂, O, SiMe₂) groups in the ortho position were generated thermally and photolytically from diazo or tosylhydrazone precursors. Stereorandom insertion reactions with 尾-C-H bonds were observed, pointing to a triplet abstraction-recombination mechanism. Large kinetic and stereochem. deuterium isotope effects support this notion. The ample formation of benzocyclobutenes from 2-CH₂-X-Ph substrates is due to insertion of the carbenes into ArCH₂-X bonds. Addition to the terminal Ph groups competes with C-H and C-X insertion. The results of benzophenone sensitization and of trapping with methanol suggest that the intramol. reactions of functionalized arylcarbenes proceed, at best, competitively with spin inversion. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6SDS of cas: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and some reactions of 2-acylcyclopentane-1,3-diones was written by Lakhvich, F. A.;Khlebnikova, T. S.;Akhrem, A. A.. And the article was included in Zhurnal Organicheskoi Khimii in 1989.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Acyloxycyclopentenones I [R = Me, hexyl, heptyl, PhCH₂, Ph, (CH₂)_nCO₂Et (n = 4-6)] were prepared in 88-97% yields by acylation of cyclopentanedione as its enol by RCOCl. Treating I with AlCl₃ in CH₂Cl₂ 3 h at -5 to 20掳 gave 68-96% acylcyclopentanediones II. Treating II [R = (CH₂)₄CO₂Et] with NH₂OH.HCl gave 86% oxime III which underwent Beckmann rearrangement to give 61% adipamic acid derivative IV. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzimidazole-based compounds kill Mycobacterium tuberculosis was written by Gong, Yaling;Somersan Karakaya, Selin;Guo, Xiaoyong;Zheng, Purong;Gold, Ben;Ma, Yao;Little, David;Roberts, Julia;Warrier, Thulasi;Jiang, Xiuju;Pingle, Maneesh;Nathan, Carl F.;Liu, Gang. And the article was included in European Journal of Medicinal Chemistry in 2014.Safety of 3-Cyanobenzoyl chloride This article mentions the following:

Tuberculosis remains one of the deadliest infectious diseases, killing 1.4 million people annually and showing a rapid increase in cases resistant to multiple drugs. New antibiotics against tuberculosis are urgently needed. Here the authors describe the design, synthesis and structure-activity relationships of a series of benzimidazole-based compounds, e.g. I [R¹ = Me, cyclobutyl, t-Bu, etc.; R² = morpholin-4-yl, thiomorpholin-4-yl; R³ = H, Me] with activity against Mycobacterium tuberculosis in a replicating state, a physiol.-induced nonreplicating state, or both. Several compounds, which shared a 5-nitrofuranyl moiety, exhibited high potency and acceptable selectivity indexes (SI). As illustrated by compound I [R¹ = isopentyl, R² = morpholin-4-yl, R³ = Me] (MIC₉₀ < 0.049 渭g/mL, SI > 512), the 5-nitrofuranyl group was compatible with minimal cytotoxicity and good intramacrophage killing, although it lacked nonreplicating activity when assessed by CFU assays. Compound I [R¹ = isopentyl, R² = morpholin-4-yl, R³ = Me] had low mutagenic potential by SOS Chromotest assay, making this class of compounds good candidates for further evaluation and target identification. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Safety of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A highly stereoselective and recyclable microgel-supported bifunctional sulfonamide organocatalyst for asymmetric alcoholysis of meso-cyclic anhydrides: a thermo-responsive “organic nanoreactor” was written by Xiong, Fei;Ma, Chao;Zhu, Yi-Ren;Sun, Chen;Chen, Lu;Zhang, Yan-Jun;Zhu, Yuan-Jie;Wang, Zhong-Hua. And the article was included in New Journal of Chemistry in 2022.Category: chlorides-buliding-blocks This article mentions the following:

A novel thermosensitive bifunctional sulfonamide microgel catalyst was synthesized by immobilization on a highly cross-linked three-dimensional network structure through covalent interactions. The microgel-supported organocatalyst was successfully applied to catalyze the asym. alcoholysis reaction in high yields and good stereoselectivity (up to 90% ee). Furthermore, the polymeric catalysts could be recovered easily and reused multiple times (5 runs) without apparent loss of catalytic activity and enantioselectivity. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Category: chlorides-buliding-blocks).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct C-H Sulfonylimination of Pyridinium Salts was written by Luo, Lihua;Tang, Juan;Sun, Rui;Li, Wenjing;Zheng, Xueli;Yuan, Maoling;Li, Ruixiang;Chen, Hua;Fu, Haiyan. And the article was included in Organic Letters in 2022.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A direct pyridinium C-H sulfonylimination has been developed for the synthesis of sulfonyl iminopyridine derivatives I (R = H, CN, Ph, thiophen-2-yl, etc.; R¹ = H, OMe, Ph, thiophen-3-yl, etc.; R² = H, cyclopropyl, Ph, 4-bromophenyl, etc.; R¹R² = -CH=CH-CH=CH-; R³ = Me, Et, i-Pr, etc.; R⁴ = Et, Ph, pyridin-3-yl, etc.) with high efficiency. This transformation features the direct and efficient formation of a C=N bond with a high functional group tolerance under metal-free conditions. The spectroscopic properties potentially enable these sulfonyl iminopyridine compounds I to be useful new emitting materials. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Study of denitrocyclization in synthesis of dibenzoxazepinones and dibenzothioazepinones was written by Sakharov, V. N.;Kalandadze, L. S.;Khristolyubova, T. A.;Smirnov, A. V.;Plakhtinskii, V. V.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2008.Computed Properties of C9H8ClNO4 This article mentions the following:

The anal. of kinetic data of intermol. nucleophilic substitution of the 2′-nitro group in series of the diphenylsulfide- and diphenyloxide-2-carboxyamides with carboxyamide group participation has been carried out. The denitrocyclization reaction has been shown to proceed with Smiles rearrangement and spiro-蟽-complex formation limited the process of the dibenzothio- or dibenzoxazepinones. No data on the formation of dibenzothio- or dibenzoxazepinones are reported. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Computed Properties of C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges was written by Nishiyama, Hiroyuki;Ono, Masahiro;Sugimoto, Takuya;Sasai, Toshio;Asakawa, Naoyuki;Yaegashi, Takashi;Nagaoka, Masato;Matsuzaki, Takeshi;Kogure, Noriyuki;Kitajima, Mariko;Takayama, Hiromitsu. And the article was included in MedChemComm in 2012.Synthetic Route of C8H4ClNO This article mentions the following:

4-Chlorocolchicine derivatives were synthesized with a view of developing new anticancer agents. The derivatives were examined for their potent activity and effective dosage range in mice, as well as favorable metabolic stability. As a result, several compounds bearing an 伪-hydroxyalkanoyl group on the C-7 amino function, were revealed to exhibit potent activities with broad effective dosage ranges. The title compounds thus formed included a colchicine amide derivative (I) and related substances. The title compounds were evaluated against N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide (colchicine). The synthesis of the target compounds was achieved using (7S)-7-amino-4-chloro-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one (4-chlorodeacetylcolchicine) as a starting material. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Synthetic Route of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient synthesis of (R)-ochratoxin alpha, the key precursor to the mycotoxin ochratoxin A was written by Lenz, Cesar Antonio;Rychlik, Michael. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 3438-16-2 This article mentions the following:

Two new routes for the synthesis of enantiomerically pure ochratoxin 伪 (I) ((3R)-OT伪) are presented, which is the key intermediate for the synthesis of ochratoxin A (OTA) by coupling reaction with the amino acid L-phenylalanine. The key step of both routes is the one pot directed ortho-metalation/alkylation/lactonization of unprotected and suitably functionalized aromatic carboxylic acids, using lithium tetramethylpiperidide (LTMP) and (R)-propylene oxide. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclic tertiary sulfamates: Selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives was written by De Monte, Celeste;Carradori, Simone;Secci, Daniela;D’Ascenzio, Melissa;Vullo, Daniela;Ceruso, Mariangela;Supuran, Claudiu T.. And the article was included in European Journal of Medicinal Chemistry in 2014.Recommanded Product: 697-73-4 This article mentions the following:

Carbonic anhydrase (hCA) IX and XII isoforms are over-expressed both in primary and in metastatic cell lines of hypoxic tumors and are innovative targets for cancer diagnosis and treatment. On the basis of the importance of the pharmacophoric sulfamate moiety (bioisostere of the sulfonamide group) present in the structure of recent human CA inhibitors, the authors designed N-alkylated I [R = CH₂:CH, MeC(O), EtO₂C, etc.] and O-alkylated derivatives II of acesulfame, a cyclic tertiary sulfamate, assessing the inhibitory activity against the ubiquitous isoforms hCA I and II and the cancer-related isoforms hCA IX and XII. All derivatives were nanomolar inhibitors, with some of them possessing an outstanding selectivity towards the tumor-associated hCA IX and/or hCA XII isoforms. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics