Month: February 2023

Reactions of perfluoroalkanesulfonyl chlorides with silyl enol ethers catalyzed by a ruthenium(II) phosphine complex was written by Kamigata, Nobumasa;Udodaira, Kumiko;Shimizu, Toshio. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 1997.Product Details of 7476-66-6 This article mentions the following:

Reactions of trifluoromethane- and tridecafluorohexanesulfonyl chlorides with silyl enol ethers have been investigated in the presence of a ruthenium(II) phosphine complex. Perfluoroalkylation and chlorination occurred depending on the substituent on the silyl enol ether, i.e., perfluoroalkylated compound was selectively obtained in the reactions with silyl enol ether possessing an electron-withdrawing group while chlorinated compounds were selectively formed in the reaction with a silyl enol ether possessing an electron-donating group. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Product Details of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives was written by Li, Yu;Shi, Qiuyan;Shao, Jiajia;Yuan, Yaping;Yang, Zhigang;Chen, Shizhen;Zhou, Xin;Wen, Shijun;Jiang, Zhong-Xing. And the article was included in European Journal of Medicinal Chemistry in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:

To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool mol. Using a K-ras cellular model, salinomycin and its derivatives showed different mol. mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nucleophilic Attack of Carbonyl-Stabilized Phosphorus Ylides on Neutral and Cationic Alkene Platinum(II) Complexes was written by Vicente, Jose;Chicote, Maria Teresa;MacBeath, Calum;Jones, Peter G.. And the article was included in Organometallics in 2003.Application In Synthesis of Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) This article mentions the following:

The carbonyl-stabilized phosphorus ylides Ph₃P:CHCO₂R (R = Me, Et) react with the platinum complexes [PtCl(畏²-CH₂:CH₂)(N,N,N’,N’-tetramethylethylenediamine)]ClO₄ and [PtCl₂(畏⁴-diene)] (diene = 1,5-hexadiene (C₆H₁₀), dicyclopentadiene (C₁₀H₁₂), 4-vinylcyclohex-1-ene (C₈H₁₂), norbornadiene (C₇H₈)) to give complexes resulting from nucleophilic attack of the ylide at one of the olefinic carbons. The crystal structures of [PtCl₂{畏³-C₆H₁₀CH(PPh₃)CO₂Et}], [PtCl₂{畏³-C₁₀H₁₂CH(PPh₃)CO₂Me}]路0.5CH₂Cl₂, and [PtCl₂{畏³-C₈H₁₂CH(PPh₃)CO₂Me}]路2CHCl₃ are reported and indicate an exo attack in the case of the dicyclopentadiene complex and anti-Markovnikov addition (attack at the CH₂ group) in the other two complexes. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Application In Synthesis of Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and characterization of a novel polyorganosiloxane having a bigger sized tubular structure and its supramolecular clathrate was written by Liu, Chunqing;Liu, Zhihua;Xie, Ping;Dai, Daorong;Zhang, Rongben;Zhu, Chuanfeng;Wang, Chen;He, Chaobin;Chung, Neal Tai-Shung. And the article was included in Polymers for Advanced Technologies in 2002.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) This article mentions the following:

A novel polyorganosiloxane having a bigger sized tubular structure, tubular polymer (TP) was synthesized successfully by hydrosilylation reaction of reactive cis-isotactic ladder-like polyallylsilsesquioxane (Allyl-T) with coupling agent p-bis(dimethylhydrogensilyl)oxydiphenylene (M) in the presence of dicyclopentadienylplatinum(II) chloride (Cp₂PtCl₂) catalyst. A novel supramol. TP clathrate (TP/LC) was prepared by in situ encapsulating rod-like liquid crystalline mol. within the pore of TP. The Allyl-T was prepared by stepwise coupling polymerization Various characterization methods including solubility test, FT-IR, ¹H-NMR, differential scanning calorimetry (DSC), gel permeation chromatog. (GPC), vapor pressure osmometer (VPO), X-ray diffraction (XRD), at. force microscopy (AFM), polarized optical microscopy (POM) and mol. simulation were used and the results not only proved the existence of nano-scale tubular structures in the TP, but also demonstrated that a novel soluble supramol. clathrate had been formed. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites was written by Harmse, Rozanne;Coertzen, Dina;Wong, Ho Ning;Smit, Frans J.;van der Watt, Mariette E.;Reader, Janette;Nondaba, Sindiswe H.;Birkholtz, Lyn-Marie;Haynes, Richard K.;N’Da, David D.. And the article was included in ChemMedChem in 2017.HPLC of Formula: 777-44-6 This article mentions the following:

Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clin. use-artemether and artesunate-induces quiescence in ring-stage parasites of Plasmodium falciparum (Pf). This induction of quiescence is linked to artemisinin resistance. Thus, we have turned to structurally disparate artemisinins that are incapable of providing DHA on metabolism Accordingly, 11-azaartemisinin 5 and selected N-sulfonyl derivatives were screened against intraerythrocytic asexual stages of drug-sensitive Pf NF54 and drug-resistant K1 and W2 parasites. Most displayed appreciable activities against all three strains, with IC₅₀ values <10.5 nM. The p-trifluoromethylbenzenesulfonyl-11-azaartemisinin derivative 11 [(4′-trifluoromethyl)benzenesulfonylazaartemisinin] was the most active, with IC₅₀ values between 2 and 3 nM. The compounds were screened against Pf NF54 early and transmissible late intraerythrocytic-stage gametocytes using luciferase and parasite lactate dehydrogenase (pLDH) assays. The 2′-thienylsulfonyl derivative 16 (2′-thiophenesulfonylazaartemisinin) was notably active against late-stage (IV-V) gametocytes with an IC₅₀ value of 8.7 nm. All compounds were relatively nontoxic to human fetal lung WI-38 fibroblasts, showing selectivity indexes of >2000 toward asexual parasites. Overall, the readily accessible 11-azaartemisinin 5 and the sulfonyl derivatives 11 and 16 represent potential candidates for further development, in particular for transmission blocking of artemisinin-resistant parasites. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quinone Reduction by Organo-Osmium Half-Sandwich Transfer Hydrogenation Catalysts was written by Bolitho, Elizabeth M.;Worby, Nathan G.;Coverdale, James P. C.;Wolny, Juliusz A.;Schunemann, Volker;Sadler, Peter J.. And the article was included in Organometallics in 2021.Application of 777-44-6 This article mentions the following:

Organo-osmium(II) 16-electron complexes [Os^II(畏⁶-arene)(R-PhDPEN)] (where 畏⁶-arene = para-cymene or biphenyl) can catalyze the reduction of prochiral ketones to optically pure alcs. in the presence of a hydride source. Such complexes can achieve the conversion of pyruvate to unnatural D-lactate in cancer cells. To improve the catalytic performance of these osmium complexes, we have introduced electron-donor and electron-acceptor substituents (R) into the para (R₁) or meta (R₂) positions of the chiral R-phenyl-sulfonyl-diphenylethylenediamine (R-PhDPEN) ligands and explored the reduction of quinones, potential biol. substrates, which play a major role in cellular electron transfer chains. We show that the series of [Os^II(畏⁶-arene)(R-PhDPEN)] derivatives exhibit high turnover frequencies, enantioselectivities (>92%), and conversions (>93%) for the asym. transfer hydrogenation (ATH) of acetophenone-derived substrates and reduce duroquinone and menadione to their di-alc. derivatives Modeling of the catalysis using d. functional theory (DFT) calculations suggests a mechanism involving formic acid deprotonation assisted by the catalyst amine groups, phenyl-duroquinone stacking, hydride transfer to Os^II, possible CO₂ coordination, and tilting of the 畏⁶-arene ring, followed by hydride transfer to the quinone. These findings not only reveal subtle differences between Ru(II) and Os(II) catalysts, but also introduce potential biol. applications. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits was written by Liu, Meng-Hua;Zhang, Qi;Zhang, Yuan-He;Lu, Xian-Yuan;Fu, Wei-Ming;He, Jing-Yu. And the article was included in Molecules in 2016.Computed Properties of C18H37Cl This article mentions the following:

Both Rosa roxburghii and R. sterilis, belonging to the Rosaceae, are endemic species in Guizhou Province, China. The fruits of these two species are mixed-used as functional food in the region. Aiming to elucidate the phytochem. characteristics of R. roxburghii and R. sterilis fruits, the essential oils and constituents in a methanol extract have been analyzed and compared by GC-MS and UFLC/Q-TOF-MS, resp. As a result, a total of 135 volatile compounds were identified by GC-MS and 91 components were different between R. roxburghii and R. sterilis fruits; a total of 59 compounds in methanol extracts were identified by UFLC/Q-TOF-MS, including 13 organic acids, 12 flavonoids, 11 triterpenes, nine amino acids, five phenylpropanoid derivatives, four condensed tannins, two stilbenes, two benzaldehyde derivatives and one benzoic acid derivative; and nine characteristic compounds were found between R. roxburghii and R. sterilis fruits. This systematic study plays an important role for R. roxburghii and R. sterilis fruits in the product development. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Computed Properties of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2 was written by Moustakim, Moses;Riedel, Kerstin;Schuller, Marion;Gehring, Andre P.;Monteiro, Octovia P.;Martin, Sarah P.;Fedorov, Oleg;Heer, Jag;Dixon, Darren J.;Elkins, Jonathan M.;Knapp, Stefan;Bracher, Franz;Brennan, Paul E.. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Category: chlorides-buliding-blocks This article mentions the following:

The polyadenosine-diphosphate-ribose polymerase 14 (PARP14) has been implicated in DNA damage response pathways for homologous recombination. PARP14 contains three (ADP ribose binding) macrodomains (MD) whose exact contribution to overall PARP14 function in pathol. remains unclear. A medium throughput screen led to the identification of N-(2(-9H-carbazol-1-yl)phenyl)acetamide (GeA-69, 1) as a novel allosteric PARP14 MD2 (second MD of PARP14) inhibitor. We herein report medicinal chem. around this novel chemotype to afford a sub-micromolar PARP14 MD2 inhibitor. This chem. series provides a novel starting point for further development of PARP14 chem. probes. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Category: chlorides-buliding-blocks).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and in vitro antimicrobial evaluation of new 1,3,4-oxadiazoles bearing 5-chloro-2-methoxyphenyl moiety was written by Basavapatna, N. Prasanna Kumar;Kikkeri, N. Mohana;Lingappa, Mallesha;Kikkeri, P. Harish. And the article was included in International Journal of Medicinal Chemistry in 2013.Electric Literature of C8H7ClO3 This article mentions the following:

A series of new 1,3,4-oxadiazole derivatives containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, ¹H NMR, mass spectra and also by elemental anal. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that some of the compounds showed significant activity against tested strains. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Electric Literature of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics