Novel synthesis with the participation of organozinc compounds. XII. Interaction of organozinc compounds with chloromethyl benzoate was written by Lapkin, I. I.;Belykh, Z. D.;Kozlova, L. S.;Fotin, V. V.. And the article was included in Zhurnal Organicheskoi Khimii in 1972.Application In Synthesis of Chloromethyl benzoate This article mentions the following:
Treatment of PhCO2CH2Cl with RCH(ZnBr)CO2R1 in absolute Et2O containing HgCl2 gave esters, PhC(OH)(OCH2CHRCO2R1)CHRCO2R1 (I, R, R1, and % yield given): Me, Me2CHCH2, 66; Et, Me, 72; Et, Et, 80; Et, Me2CH, 59; Et, Bu, 78; Et, Me2CHCH2, 72; Et, pentyl, 57. I readily dehydrated to give PhC(OCH2CHRCO2R1):CRCO2R1 (R, R1, and % yield given): Me2CH, Et, 86; Me2CH, Pr, 80; Me2CH, Bu, 84; Me2CH, Me2CHCH2, 76; Me2CH, pentyl, 86; Me2CH, hexyl, 86. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).
Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of Chloromethyl benzoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics