A Four-Component Reaction Strategy for Pyrimidine Carboxamide Synthesis was written by Guo, Wei;Liao, Jianhua;Liu, Dongqing;Li, Jiawei;Ji, Fanghua;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Angewandte Chemie, International Edition in 2017.Name: 2-Chloro-benzamidine hydrochloride This article mentions the following:
Demonstrated herein is a highly effective 3 starting materials and 4 component reaction (3SM-4CR) strategy for the synthesis of pyrimidinecarboxamides from amidines, styrenes, and N,N-dimethylformamide (DMF) by a palladium-catalyzed oxidative process. This transformation represents the first example of employing DMF as a dual synthon, a one-carbon-atom synthon and amide synthon, and was proven by isotope-labeling experiments Addnl., the combination of C-H bond functionalization and cross-dehydrogenative coupling processes affords four chem. bond formations. This sequential 3SM-4CR strategy features inexpensive, readily available starting materials, green oxidants, as well as atom and step economy. It leads to the preparation of pyrimidine carboxamides and has potential applications in the pharmaceutical industry. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Name: 2-Chloro-benzamidine hydrochloride).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 2-Chloro-benzamidine hydrochloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics