A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core was written by Fotsch, Christopher;Biddlecome, Gloria;Biswas, Kaustav;Chen, Jian Jeff;D’Amico, Derin C.;Groneberg, Robert D.;Han, Nianhe Bruce;Hsieh, Feng-Yin;Kamassah, Augustus;Kumar, Gondi;Lester-Zeiner, Dianna;Liu, Qingyian;Mareska, David A.;Riahi, Babak Bobby;Wang, Yueh-Ju Judy;Yang, Kevin;Zhan, James;Zhu, Joe;Johnson, Eileen;Ng, Gordon;Askew, Benny C.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Related Products of 1138-56-3 This article mentions the following:
The bradykinin 1 (B1) receptor is upregulated during times of inflammation and is important for maintaining inflamed and chronic pain states. Blocking this receptor has been shown to reverse and/or ameliorate pain and inflammation in animal models. In this report, we describe a new class of B1 receptor antagonists that contain the piperidine acetic acid tetralin core. A structure-activity relationship for these analogs is described in this paper. The most potent compounds from this class have IC50s < 20 nM in a B1 receptor functional assay. One of these compounds, I, shows modest oral bioavailability in rats. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Related Products of 1138-56-3).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 1138-56-3
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics