Dogan, Hilal et al. published their research in European Journal of Medicinal Chemistry in 2020 | CAS: 6590-96-1

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6590-96-1

Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors was written by Dogan, Hilal;Dogan, Sengul Dilem;Gunduz, Miyase Gozde;Krishna, Vagolu Siva;Lherbet, Christian;Sriram, Dharmarajan;Sahin, Onur;Saripinar, Emin. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 6590-96-1 This article mentions the following:

The rational design and synthesis of eighteen new thiadiazolylhydrazones I [R1 = H, Me; R2 = H, Cl; R3 = H, Me, NO2, etc.] which were synthesized by intramol. oxidative N-S bond formation reaction of 2-benzylidene-N-(phenylcarbamothioyl)hydrazine-1-carboximidamide derivatives II by phenyliodine(III) bis(trifluoroacetate) (PIFA) under mild conditions were presented. Furthermore, the proposed structure of compounds I [R1 = Me, R2 = H, R3 = MeO] was resolved by single-crystal X-ray anal. The compounds I were evaluated for their in vitro antitubercular activity against M. tuberculosis H37Rv. Among them, some compounds I exhibited remarkable antimycobacterial activity, MIC = 0.78-6.25渭g/mL, with low cytotoxicity. Addnl., the most active compounds were screened for their biol. activities against M. tuberculosis in nutrient starvation model. Enzyme inhibition assays and mol. docking studies revealed enoyl acyl carrier protein reductase (InhA) as the possible target enzyme of compounds to show their antitubercular activities. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Related Products of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics