Zou, Fangxia et al. published their research in European Journal of Medicinal Chemistry in 2022 | CAS: 697-73-4

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 697-73-4

Discovery of the thieno[2,3-d]pyrimidine-2,4-dione derivative: A potent and orally bioavailable gonadotropin-releasing hormone receptor antagonist was written by Zou, Fangxia;Wang, Yao;Yu, Dawei;Liu, Chunjiao;Lu, Jing;Zhao, Min;Ma, Mingxu;Wang, Wenyan;Jiang, Wanglin;Gao, Yonglin;Zhang, Rui;Zhang, Jianzhao;Ye, Liang;Tian, Jingwei. And the article was included in European Journal of Medicinal Chemistry in 2022.Recommanded Product: 697-73-4 This article mentions the following:

Here, rationally designed and synthesized a series of derivatives (I [R1 = 2-(2,6-difluorophenyl)ethyl, 2-[2-fluoro-6-(trifluoromethyl)phenyl]ethyl, 2-(3,5-difluoropyridin-4-yl)ethyl; R2 = (2-fluoro-3-methoxyphenyl)methyl, [4-(2,2,2-trifluoroethoxy)phenyl]methyl, [3-(difluoromethoxy)-2-fluorophenyl]methyl, etc] and II [R3 = methoxymethyl, cyclobutoxymethyl, (cyclopropylmethoxy)methyl; R4 = 2-(dimethylamino)ethyl, 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl, 2-[(3S)-3-methoxypyrrolidin-1-yl]ethyl, etc]) through the modification and structure-activity relationship study of relugolix, which led to the discovery of II [R3 = methoxymethyl, R4 = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] as a highly potent GnRH-R antagonist (IC50 = 2.18 nM) with improved membrane permeability (Papp, A-B = 0.98 x 10-6 cm/s) and oral bioavailability (F % = 44.7). CompoundII [R3 = methoxymethyl, R4 = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] showed high binding affinity (IC50 = 0.57 nM) and potent in vitro antagonistic activity (IC50 = 2.18 nM) at GnRH-R. II [R3 = methoxymethyl, R4 = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] was well tolerated and efficacious in preclin. studies to suppress blood testosterone levels, which merits further investigation as a candidate novel GnRH-R antagonist for clin. studies. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics