Novel Ferulic Amide Ac6c Derivatives: Design, Synthesis, and Their Antipest Activity was written by Zhang, Renfeng;Guo, Shengxin;Deng, Peng;Wang, Ya;Dai, Ali;Wu, Jian. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:
Thirty-eight novel ferulic amide 1-aminocyclohexane carboxylic acid (Ac6c) derivatives D1-D19 (I) wherein R is CH3-Ph, Cl-Ph, CF3-Ph, etc.; and E1-E19 (II) wherein R is CH3-Ph, Cl-Ph, CF3-Ph, etc.; were designed and synthesized, and their antibacterial, antifungal, and insecticidal activities were tested. Most of the synthesized compounds displayed excellent activity against Xanthomonas oryzae pv. oryzae (Xoo), with EC50 values ranging from 11.6 to 83.1μg/mL better than that of com. bismerthiazol (BMT, EC50 = 84.3μg/mL), as well as much better performance compared to that of thiediazole copper (TDC, EC50 = 137.8μg/mL). D6 (EC50 = 17.3μg/mL), D19 (EC50 = 29.4μg/mL), E3 (EC50 = 29.7μg/mL), E9 (EC50 = 27.0μg/mL), E10 (EC50 = 18.6μg/mL), and E18 (EC50 = 20.8μg/mL) showed much higher activity on Xanthomonas oryzae pv. oryzicola compared with BMT (EC50 = 80.1μg/mL) and TDC (EC50 = 124.7μg/mL). In relation to controlling the fungus, Rhizoctonia solani, E1, E10, and E13 had much lower EC50 values of 0.005, 0.140, and 0.159μg/mL compared to hymexazol at 74.8μg/mL. Further in vivo experiments demonstrated that E6 and E12 controlled rice bacterial leaf blight disease better than BMT and TDC did. SEM studies revealed that E12 induced the Xoo cell membrane collapse. Moreover, D13 (73.7%), E5 (80.6%), and E10 (73.4%) also showed moderate activity against Plutella xylostella. These results indicated that the synthesized ferulic amide Ac6c derivatives showed promise as candidates for treating crop diseases. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics