Targeted covalent inhibition of O-GlcNAc transferase in cells was written by Worth, Matthew;Hu, Chia-Wei;Li, Hao;Fan, Dacheng;Estevez, Arielis;Zhu, Dongsheng;Wang, Ao;Jiang, Jiaoyang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Application In Synthesis of (E)-4-Chlorobut-2-enoic acid This article mentions the following:
O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect other functionally similar enzymes. This study provides a new strategy to interrogate cellular OGT functions and to investigate other glycosyltransferases. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Application In Synthesis of (E)-4-Chlorobut-2-enoic acid).
(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of (E)-4-Chlorobut-2-enoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics