Chromium(II)-Mediated Reformatskii Reactions of Carboxylic Esters with Aldehydes was written by Wessjohann, Ludger;Gabriel, Tobias. And the article was included in Journal of Organic Chemistry in 1997.Formula: C9H9ClO2 This article mentions the following:
Chromium dichloride reacts with α-halo esters and aldehydes in a Barbier-type reaction to give β-hydroxy esters in good to excellent yield. The reaction is of excellent reproducibility and chemoselectivity and suitable for microscale preparations and the construction of quaternary centers. The simple diastereoselectivity is preferentially anti and contrasts with that of comparable Reformatskii reactions. The effects of substituents, temperature, halogen, and additives are discussed briefly. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Formula: C9H9ClO2).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics