Li, Wei-Yi et al. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020 | CAS: 6834-42-0

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 2-(3-Methoxyphenyl)acetyl chloride

N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation was written by Li, Wei-Yi;Ni, Wei-Wei;Ye, Ya-Xi;Fang, Hai-Lian;Pan, Xing-Ming;He, Jie-Ling;Zhou, Tian-Li;Yi, Juan;Liu, Shan-Shan;Zhou, Mi;Xiao, Zhu-Ping;Zhu, Hai-Liang. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which act as effective urease inhibitors with very low cytotoxicity. One compound () was evaluated in detail and shows promising features for further development as an agent to treat H. pylori caused diseases. Excellent values for the inhibition of against both extracted urease and urease in intact cell were observed, which shows IC50 values of 0.16 ± 0.05 and 3.86 ± 0.10μM, being 170- and 44-fold more potent than the clin. used drug AHA, resp. Docking simulations suggested that the monosubstituted thiourea moiety penetrates urea binding site. In addition, is a rapid and reversible urease inhibitor, and displays nM affinity to urease with very slow dissociation (koff=1.60 × 10-3 s-1) from the catalytic domain. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics