New phorbol ester derivatives as potent anti-HIV agents was written by Li, Qi-Run;Cheng, Yung-Yi;Zhao, Lei;Huang, Xiao-Lei;Jiang, Xiao-Gang;Cui, Ya-Dong;Morris-Natschke, Susan L.;Goto, Masuo;Chen, Chin-Ho;Lee, Kuo-Hsiung;Chen, Dao-Feng;Zhang, Jian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Recommanded Product: (Chloromethanetriyl)tribenzene This article mentions the following:
Tigliane esters show many biol. activities, including anti-HIV-1 activity. Our aim in this study was to establish structure-anti-HIV activity relationships for four series of tigliane-type diterpenoids. We synthesized and evaluated 29 new phorbol ester derivatives for anti-HIV activity and for cytotoxicity against human tumor cell lines. Among them, three derivatives, two phorbol-13-monoesters (5d and 5e) and a phorbol-12,13-diester (6a), showed significant anti-HIV activity. We found that better anti-HIV activity was often associated with a shorter acyl ester at C-13. Particularly, compounds with a Ph ring in the ester side chain exhibited excellent anti-HIV activity and had good safety indexes. Due to its significant anti-HIV potency with a high selectivity index, phorbol-12,13-dicinnamoate (6a) was chosen as the potential candidate for further preclin. trials. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: (Chloromethanetriyl)tribenzene).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: (Chloromethanetriyl)tribenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics