Thioglycoluril as a highly efficient, recyclable and novel organocatalyst for N-Boc protection of amines was written by Khaksar, Samad;Vahdat, Seyed Mohammad;Tajbakhsh, Mahmood;Jahani, Fatemeh;Heydari, Akbar. And the article was included in Tetrahedron Letters in 2010.Reference of 18437-66-6 This article mentions the following:
A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-Bu dicarbonate using thioglycoluril as the catalyst is described. The catalyst can be readily separated from the reaction products by simple filtration and recovered for reuse. No competitive side reactions, such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were observed In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics