From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor was written by Borukhova, Svetlana;Noel, Timothy;Metten, Bert;de Vos, Eric;Hessel, Volker. And the article was included in Green Chemistry in 2016.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:
Rufinamide can be synthesized from 2,6-difluorobenzyl chloride in three steps. The microreactor flow networks have better sustainability profiles in terms of life-cycle assessment than the resp. consecutive processing in a batch. The anal. is based on the results of a single step conversion from batch to continuous mode. An uninterrupted continuous process towards rufinamide is developed, starting from 2,6-difluorobenzyl alc. precursor, which is converted to the corresponding 2,6-difluorobenzyl chloride with hydrogen chloride gas. The chloride is then converted to the corresponding 2,6-difluorobenzyl azide that yields the rufinamide precursor I via cycloaddition to the greenest and cheapest dipolarophile available on the market. The current process demonstrates chem. and process-design intensification aspects encompassed by novel process windows. Single reaction steps are chem. intensified via a wide range of conditions available in a microreactor environment. Meanwhile, the connection of reaction steps and separations results in process-design intensification. With two in-line separations the process consists of five stages resulting in a total yield of 82% and productivity of 9 g h-1 (11.5 mol h-1L-1). The process minimizes the isolation and handling of strong alkylating or energetic intermediates, while minimizing water and organic solvent consumption. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics