Synthesis and antitumor activity of (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazide was written by Bhole, Ritesh P.;Bhusari, Kishore P.. And the article was included in Medicinal Chemistry Research in 2011.Reference of 6590-96-1 This article mentions the following:
To examine new drug leads with potential anticancer activity, some (4-hydroxyphenyl)[5-substituted alkyl/aryl-2-thioxo-1,3,4-thiadiazol-3-yl]methanones e.g., I and [-(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazides e.g., II were synthesized using appropriate synthetic route. The newly prepared compounds, e.g., I and II demonstrated inhibitory effects on the growth of a wide range of cancer cell lines especially on leukemia (HL-60), non-small lung cancer (HOP-92), renal cancer (ACHN) at the range of GI50 -4.23 to -7.23. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6590-96-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics