Monosaccharide derivatives: synthesis, antimicrobial, pass, antiviral and molecular docking studies against SARS-CoV-2 Mpro inhibitors was written by Yasmin, Farhana;Amin, Mohammed R.;Hosen, Mohammed A.;Bulbul, Mohammed Z. H.;Dey, Sujan;Kawsar, Sarkar M. A.. And the article was included in Cellulose Chemistry and Technology in 2021.Related Products of 76-83-5 This article mentions the following:
Several carbohydrate-based drugs are currently being used to treat a number of diseases in humans worldwide. Thus, our research group has focused on the synthesis of new Me α-D-mannopyranoside (MDM) derivatives and their antimicrobial evaluation through computational studies. A series of MDM derivatives (2-6) were synthesized through facile regioselective acylation, using the direct method affording 6-O-(3-chlorobenzoyl) derivatives This isolated 6-O-derivative was further transformed to 2,3,4-tri-O-acyl derivatives, bearing a wide variety of functionalities in a single mol. framework. The structures of the newly designed mols. were elucidated with the aid of IR, 1H NMR, mass spectroscopy, and elemental anal. The prediction of the activity spectra for the compounds (PASS) and their in vitro antimicrobial evaluation were performed, demonstrating them to be potential antimicrobial agents. The antimicrobial tests demonstrated that the compounds 3 and 5 were the most potent with the min. inhibitory concentration (MIC) values, ranging from 0.312 ± 0.01 to 1.25 ± 0.03 mg/mL, and min. bactericidal concentration (MBC) values, ranging from 0.625 ± 0.02 to 2.50 ± 0.05 mg/mL. A quantum chem. study was performed to calculate the thermodn., MO and electrostatic potential properties of the designed compounds Mol. docking simulation was carried out against SARS-CoV-2 Mpro protein 7BQY and 6Y84 to investigate their binding energy and binding tactics with the viral protein, and better binding affinity than that of the parent drug was observed Also, pharmacokinetic prediction revealed an improved drug-likeness profile for all MDM derivatives In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Related Products of 76-83-5).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 76-83-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics