Synthesis of 6-alkyloxy-3,4-dihydro-2(1H)-quinolinones and their anticonvulsant activities was written by Quan, Zhe-Shan;Wang, Jun-Min;Rho, Jung-Rae;Kwak, Kyung-Chell;Kang, Hee-Cheol;Jun, Chang-Soo;Chai, Kyu-Yun. And the article was included in Bulletin of the Korean Chemical Society in 2005.Application of 697-73-4 This article mentions the following:
A series of 6-alkyloxy-3,4-dihydro-2(1H)-quinolinones were synthesized through nitration, reduction, diazotization, hydrolysis, and alkylation from 3,4-dihydro-2(1H)-quinolinone. Their structures were characterized by IR, 1H-NMR, and MS. The anticonvulsant activity was evaluated by the maximal electroshock test (MES) and the s.c. pentylenetetrazole (metrazole) test (scMet). The neurotoxicity was measured by the rotarod test (Tox). The result showed that 6-hexyloxy-3,4-dihydro-2(1H)-quinolinone was potent in anti-MES and anti-scMet test with ED50 of 24.0 and 21.2 mg/kg, resp., albeit its TD50 (67.6 mg/kg) revealed the high neurotoxicity. 6-Benzyloxy-3,4-dihydro-2(1H)-quinolinone was less effective against MES-induced seizure with ED50 of 29.6 mg/kg, but no neurotoxicity was observed even <300 mg/kg. Its protective index (PI) was >10 preferable to phenytoin, carbamazepin, phenobarbital, and valproate. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Application of 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics