Selective Angiotensin II AT2 Receptor Agonists: Arylbenzylimidazole Structure-Activity Relationships was written by Wu, Xiongyu;Wan, Yiqian;Mahalingam, A. K.;Murugaiah, A. M. S.;Plouffe, Bianca;Botros, Milad;Karlen, Anders;Hallberg, Mathias;Gallo-Payet, Nicole;Alterman, Mathias. And the article was included in Journal of Medicinal Chemistry in 2006.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:
Structural alterations in the 2- and 5-positions of the first drug-like selective angiotensin II AT2 receptor agonist I have been performed. The imidazole ring system was proven to be a strong determinant for the AT2 selectivity, and with few exceptions all variations gave good AT2 receptor affinities and with retained high AT2/AT1 selectivities. On the contrary to the findings with AT1 receptor agonists, the impact of structural modifications in the 5-position of the AT2 selective compounds were less pronounced regarding activation of the AT2 receptor. The butyloxyphenyl (56) and the propylthienyl (50) derivatives were found to exert a high agonistic effect as deduced from their capacity to induce neurite elongation in neuronal cells, as does angiotensin II. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics