Octanol/water partition coefficient of ortho-substituted aromatic solutes was written by Sotomatsu, Tomoko;Shigemura, Masao;Murata, Yoshiyuki;Fujita, Toshio. And the article was included in Journal of Pharmaceutical Sciences in 1993.Synthetic Route of C7H4ClNO4 This article mentions the following:
The partition coefficient (P) of some mono- and di-ortho-substituted aromatic compounds was measured in a 1-octanol/water system. For each series of compounds with the same functional group, the π value (the difference in the log P value between the substituted and unsubstituted compound) was analyzed on the same basis as the values of m- and p-substituted isomers by an extended Hammett-Taft procedure. In the procedure, the authors considered the intramol. electronic and steric effects, operating between substituents and governing the relative hydrogen-bonding solvation with partitioning solvents for solutes in which internal hydrogen-bond formation can be ignored. The π value for mono- and di-ortho-substituted derivatives was adequately included in the correlation equation for the values of the m- and p-substituted derivatives in each series. The effect of di-ortho substituents on partition behaviors could be roughly expressed by the sum of the effects of the 2- and 6-position substituents. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Synthetic Route of C7H4ClNO4).
2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClNO4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics