Unprecedented Access to β-Arylated Selenophenes through Palladium-Catalyzed Direct Arylation was written by Skhiri, Aymen;Ben Salem, Ridha;Soule, Jean-Francois;Doucet, Henri. And the article was included in Chemistry – A European Journal in 2017.Category: chlorides-buliding-blocks This article mentions the following:
The Pd-catalyzed coupling of benzenesulfonyl chlorides RS(O)2Cl (R = 4-H3CC6H4, 3,5-Cl2C6H3, naphthalen-1-yl, etc.) with selenophenes I (R1 = H, 4-H3COC6H4, 3-F3CC6H4; R2 = H, Br, 4-H3CC6H4, etc.; R3 = H) affording regiospecific β-arylated selenophenes II is reported. The reaction proceeds with easily accessible catalyst, base and substrates, and tolerates a variety of substituents both on the benzene and selenophene moieties. This transformation allows the programmed synthesis of polyarylated selenophenes II (R = 4-F3CC6H4, 4-H3COC6H4; R1 = H, 4-O2NC6H4; R2 = 4-H3CC(O)C6H4, 4-NCC6H4; R3 = 4-ClC6H4, 4-NCC6H4) with potential applications in pharmaceutical and materials chem., as the installation of aryl groups at the desired positions can be achieved. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics