Catalytic reduction of organic halogen compounds was written by Rosenmund, Karl W.;Zetzsche, Fritz. And the article was included in Berichte der Deutschen Chemischen Gesellschaft in 1918.Synthetic Route of C4H5ClO2 This article mentions the following:
Colloidal Pd protected with gum arabic or palladinized BaSO4 is an efficient catalyst in the removal of halogen from organic compounds with H and it is usually advisable to have an alkali present to neutralize the halogen acid as it is formed. Many substances react even if merely suspended in aqueous alkalies. In halogen derivatives of ethylenic compounds the halogen may sometimes be removed without saturating the C:C linking or the halogen derivative of the saturated compound may be formed. Frequently the reaction proceeds smoothly to hydrogenation and removal of the halogen. With dihalogen compounds it is apparently impossible to obtain mono-derivatives As illustrations the following reductions are described: PhBr to C6H6, o-BrC6H4CO2H, to BzOH, p-BrC6H4NO2 to PhNH2, chlorocaffeine to caffeine, chlorocrotonic to crotonic acid, o-ClC6H4CH:CHCO2H to PhCH2-CH2CO2H, (CHBrCO2H)2 to (CH2CO2H)2. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Synthetic Route of C4H5ClO2).
(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C4H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics