Concise synthesis of 3,4-dihydro-1,4-benzoxazines by three-component reactions of acyl chlorides, o-aminophenols and 1,2-dichloroethane was written by Liu, Yunyun;Chen, Xuwen. And the article was included in Tetrahedron in 2018.Product Details of 6834-42-0 This article mentions the following:
The Cu(OAc)2-catalyzed three-component reactions of o-aminophenols R1-2-NH2C6H3OH (R1 = H, 4-CH3, 5-CH3), acyl chlorides R2C(O)Cl (R2 = C6H5, furan-2-yl, (E)-C6H5CH=CH, etc.) and 1,2-dichloroethane (DCE) have been established for the efficient synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazines (3,4-dihydro-1,4-benzoxazines) I (R3 = H, 6-CH3, 7-CH3). This method features advantages of the one-pot operation enabling N-acylation, C-Cl bond amidation and etherification, as well as the structural divergence of the synthesized products. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Product Details of 6834-42-0).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 6834-42-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics