Liu, Hu et al. published their research in Journal of Medicinal Chemistry in 2018 | CAS: 165047-23-4

2-Chloro-4,5-difluorobenzaldehyde (cas: 165047-23-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 165047-23-4

Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies was written by Liu, Hu;Tian, Ye;Lee, Kyungae;Krishnan, Pranav;Wang, May Kwang-Mei;Whelan, Sean;Mevers, Emily;Soloveva, Veronica;Dedic, Benjamin;Liu, Xinyong;Cunningham, James M.. And the article was included in Journal of Medicinal Chemistry in 2018.Recommanded Product: 165047-23-4 This article mentions the following:

Previous studies identified an adamantane dipeptide piperazine 3.47 that inhibits Ebola virus (EBOV) infection by targeting the essential receptor Niemann-Pick C1 (NPC1). The physicochem. properties of 3.47 limit its potential for testing in vivo. Optimization by improving potency, reducing hydrophobicity, and replacing labile moieties identified 3.47 derivatives with improved in vitro ADME properties that are also highly active against EBOV infection, including when tested in the presence of 50% normal human serum (NHS). In addition, 3A4 was identified as the major cytochrome P 450 isoform that metabolizes these compounds, and accordingly, mouse microsome stability was significantly improved when tested in the presence of the CYP3A4 inhibitor ritonavir that is approved for clin. use as a booster of anti-HIV drugs. Oral administration of the EBOV inhibitors with ritonavir resulted in a pharmacokinetic profile that supports a b.i.d. dosing regimen for efficacy studies in mice. In the experiment, the researchers used many compounds, for example, 2-Chloro-4,5-difluorobenzaldehyde (cas: 165047-23-4Recommanded Product: 165047-23-4).

2-Chloro-4,5-difluorobenzaldehyde (cas: 165047-23-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 165047-23-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics