One stone two birds: cobalt-catalyzed in-situ generation of isocyanates and benzyl alcohols for the synthesis of N-aryl carbamates was written by Li, Sida;Khan, Ruhima;Zhang, Xia;Yang, Yong;Wang, Zheting;Zhan, Yong;Dai, Yuze;Liu, Yue-e;Fan, Baomin. And the article was included in Organic & Biomolecular Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:
An efficient method for the synthesis of N-aryl carbamates RNHC(O)OR1 [R = Ph, 4-FC6H4, 4-O2NC6H4, etc.; R1 = Et, Bn, 4-BrC6H4CH2, etc.] from N-Boc-protected amines and benzyl formates/alcs. was developed. The cobalt-catalyzed in situ generation of isocyanates from N-Boc-protected amines and benzyl alcs. from benzyl formates was achieved for the first time, which in turn furnished the corresponding benzyl carbamates in moderate to high yields. The reaction was catalyzed by CoI2 with tris-(4-dimethylaminophenyl)-phosphine as the ligand and zinc powder as the reductant. The developed reaction conditions were found to be compatible for aromatic amines with both electron-donating and -withdrawing substituents. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics