Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors was written by Di Matteo, Mauro;Ammazzalorso, Alessandra;Andreoli, Federico;Caffa, Irene;De Filippis, Barbara;Fantacuzzi, Marialuigia;Giampietro, Letizia;Maccallini, Cristina;Nencioni, Alessio;Parenti, Marco;Soncini, Debora;Del Rio, Alberto;Amoroso, Rosa. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Electric Literature of C8H9ClO4S This article mentions the following:
The most frequently used treatment for hormone receptor pos. breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC50 values that are similar to that of letrozole and SYN 20028567 were identified. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H9ClO4S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics