Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions was written by Deng, Xingwang;Zhou, Guan;Tian, Jing;Srinivasan, Rajavel. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 76-83-5 This article mentions the following:
We report the facile amide-forming ligation of acylsilanes R1COSiMe3 with hydroxylamines R2NHOCONEt2 (ASHA ligation) under aqueous conditions, yielding amides R1CONHR2 in a chemoselective way in MeCN/H2O mixtures catalyzed by citric acid. The ligation is fast, chemoselective, mild, high-yielding and displays excellent functional-group tolerance. Late-stage modifications of an array of marketed drugs, peptides, natural products, and biol. active compounds showcase the robustness and functional-group tolerance of the reaction. The key to the success of the reaction could be the possible formation of the strong Si-O bond via a Brook-type rearrangement. Given its simplicity and efficiency, this ligation has the potential to unfold new applications in the areas of medicinal chem. and chem. biol. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 76-83-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics