Synthesis of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides and their evaluation as D3 receptor ligands was written by Blass, Benjamin E.;Chen, Peng-Jen;Gordon, John C.. And the article was included in Medicinal Chemistry Research in 2022.COA of Formula: C19H15Cl This article mentions the following:
Cocaine use disorder (CUD) is a major, unmet medical need. This tropane alkaloid is one of the most commonly abused recreational drugs. In 2018, there were over 5.5 million cocaine users. Therapeutic options capable of addressing this issue are limited, as there are no approved pharmacotherapies. The D3 dopamine receptor is a potential CUD therapeutic target that remains under active investigation. We have recently disclosed a series of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides typified by I that are potent D3 ligands that have moderate to high selectivity for D3 over D2. We have continued our exploration of this series of compounds in an effort to identify compounds with improved microsomal stability such as II. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C19H15Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics