Effect of meta-substituents on aromatic nucleophilic substitution was written by Bevan, C. W. L.;Hirst, J.;Una, S. J.. And the article was included in Chemistry & Industry (London, United Kingdom) in 1966.Recommanded Product: 4815-64-9 This article mentions the following:
Displacement of F in 3,5-R(O2N)C6H3F by OMe ions in MeOH varied by a factor of 104 depending on the group R. The rate decreased as A varied in the order NO2 > SO2Me > CF3 > Br > Cl > I > F > Ac > H > OMe > Me > CMe3 > CO2– > NH2. For PhF (no other substituent on the ring), the rate was 10-4 which was the slowest of the meta-nitro-substituted series. All reactions were run at 100°. Despite an overall difference of 108 in rates, the log B factor in the Arrhenius equation k = Be-Ε/RT remained constant at approx. 12.5. The vast difference in rates was attributed to the changes in the activation energy. The reaction series was sensitive to electronic effects. Somewhat abnormal results, obtained where R was NH2 or OMe, were attributed to 2nd-order effects in reactions especially sensitive to the charge d. on the C atoms ortho to that bonded to F. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9Recommanded Product: 4815-64-9).
1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 4815-64-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics