U-87947E, a potent quinolone antibacterial agent incorporating a bicyclo[1.1.1]pent-1-yl (BCP) subunit was written by Barbachyn, Michael R.;Hutchinson, Douglas K.;Toops, Dana S.;Reid, Raymond J.;Zurenko, Gary E.;Yagi, Betty H.;Schaadt, Ronda D.;Allison, John W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1993.Application of 96568-04-6 This article mentions the following:
Incorporation of a bicyclo[1.1.1]pent-1-yl group at the N-1 position of quinolone antibacterial agents affords compounds with potent activity. One of these analogs, I.MeSO3H (U-87947E), exhibits enhanced activity relative to that of ciprofloxacin against gram-pos. aerobic bacteria and anaerobic organisms. Time-kill kinetic studies reveal that U-87947E is exquisitely bactericidal against ciprofloxacin-resistant Staphylococcus aureus. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Application of 96568-04-6).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 96568-04-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics