Synthesis and antimicrobial evaluation of nitazoxanide-based analogs: Identification of selective and broad spectrum activity was written by Ballard, T. Eric;Wang, Xia;Olekhnovich, Igor;Koerner, Taylor;Seymour, Craig;Salamoun, Joseph;Warthan, Michelle;Hoffman, Paul S.;MacDonald, Timothy L.. And the article was included in ChemMedChem in 2011.Synthetic Route of C5H2Cl2O2S This article mentions the following:
A library composed of nitazoxanide-based analogs was synthesized and assayed for increased antibacterial efficacy against the pyruvate-ferredoxin oxidoreductase (PFOR) using microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitulate and improve activity against these organism,s and select analogs were tested for their ability to disrupt the PFOR enzyme directly. The library was also screened for activity against staphylococci and resulted in the identification of analogs capable of inhibiting both staphylococci and all PFOR organisms at low micromolar min. inhibitory concentrations with low toxicity to human foreskin cells. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Synthetic Route of C5H2Cl2O2S).
2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C5H2Cl2O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics