Intramolecular reactions of N-nitrenes: oxidation of 3-amino-2-(arylalkyl)quinazolin-4(3H)-ones was written by Atkinson, Robert S.;Malpass, John R.;Woodthorpe, Katherine L.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1982.Synthetic Route of C9H9ClO2 This article mentions the following:
Oxidation of quinazolines I (R = OMe; R1 = H, OMe; R2 = NH2; n = 2) with Pd(OAc)4 in CH2Cl2 at room temperature gave I (same R, R1, n; R2 = H) (II) and the diazepines III (R = H, OMe; R1 ≠ R2 = H, OMe) via the corresponding N-nitrene intermediates. On oxidation under analogous conditions I (n = 2, R = H, R1 = OMe; n = 1, R ≠ R1 = H, OMe; R2 = NH2) gave only the deamination products II. Azepine formation involves electrophilic aromatic substitution by the nitrene on the aromatic ring via a 7-membered transition state. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics