Progress in synthesis of intermediates for quinolone antibacterial agents was written by Xu, Zhaoyu. And the article was included in Huagong Keji Shichang in 2009.Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:
New advance of some important intermediates for synthesizing quinolone antibacterial was introduced. These intermediates include 2,3,4-trifluoronitrobenzene, 2,4-dichloro-5-fluorobenzoic acid, 4-n-butyryl chloride, and ethyl-2,6-dichloro-5-fluoro nicotinoyl acetate, and 2,4-dichloro fluorobenzene etc. In addition, expounded improvement of some synthetic methods, such as 2,4-dichloro fluorobenzene, 2,4-dichloro-5-fluorobenzoic acid, etc. In synthesis of 1,2,3-trifluoro-4-nitrobenzene by two processes of nitration and fluorination with 1,2,3-trichlorobenzene as raw material, content of product was over 99%, and yield was 60%. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics