Design, synthesis and preliminary biological evaluation of benzylsulfone coumarin derivatives as anti-cancer agents was written by Wang, Tao;Peng, Tao;Wen, Xiaoxue;Wang, Gang;Sun, Yunbo;Liu, Shuchen;Zhang, Shouguo;Wang, Lin. And the article was included in Molecules in 2019.Name: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
In this work, a series of benzylsulfone coumarin derivatives I (5a-5o) R1 = 4-Me, 2-Br, 3-F, etc.; R2 = H, NO2, Br) were synthesized and characterized. Kinase inhibitory activity assay indicated that most of the compounds showed considerable activity against PI3K. Anti-tumor activity studies of the active compounds were also carried out in vitro on the Hela, HepG2, H1299, HCT-116, and MCF-7 tumor cell lines by MTS assay. The structure-activity relationships (SARs) of these compounds were analyzed in detail. Compound 5h (R1 = 4-F, R2 = NO2) exhibited the most potent activities against the mentioned cell lines with IC50 values ranging from 18.12 to 32.60μM, followed by 5m (R1 = 4-F, R2 = Br) with IC50 values of 29.30-42.14μM. Furthermore, 5h and 5m clearly retarded the migration of Hela cells in vitro. Next, an in silico mol. docking study was conducted to evaluate the binding models of 5h and 5m towards PI3Kα and PI3Kβ. Collectively, the above findings suggested that compounds 5h and 5m might be promising PI3K inhibitors deserving further investigation for cancer treatment. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Name: 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics