Enantioselective One-pot Synthesis of 3-Azabicyclo[3.1.0]hexanes via Allylic Substitution and Oxidative Cyclization was written by Chaki, Bijan Mohon;Takenaka, Kazuhiro;Zhu, Linpeng;Tsujihara, Tetsuya;Takizawa, Shinobu;Sasai, Hiroaki. And the article was included in Advanced Synthesis & Catalysis in 2020.Application In Synthesis of 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:
An enantioselective one-pot synthesis of 3-azabicyclo[3.1.0]hexanes I (R = (2,4-dimethoxyphenyl)sulfonyl, mesyl, tosyl, etc.; R1 = Me, Ph, thiophen-2-yl, etc.; R2 = Me, cyano, benzoyl, etc.) from allyl carbonates R2C(=CH2)CH2OBoc and propargyl amines RNHCH2CCR1 was reported. An amine catalyst promoted the allylic substitution to form intermediary N-allyl propargylamines RN(CH2C(=CH2)R2)CH2CCR1, which underwent enantioselective Pd(II)/Pd(IV)-mediated oxidative cyclization in situ. The chiral ligand (P,R,R)-i-Pr-SPRIX is crucial to the cyclization, producing the desired bicyclic compounds in up to 92% yield and 90% ee. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application In Synthesis of 2,4-Dimethoxybenzene-1-sulfonyl chloride).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2,4-Dimethoxybenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics